MET alterations and their impact on the future of non-small cell lung cancer (NSCLC) targeted therapies

Autor:	Patrick C. Ma, Balazs Halmos, Feng Wang, Prantesh Jain, Matthew Lee, Alain C. Borczuk
Rok vydání:	2021
Předmět:	0301 basic medicine Immunoconjugates Lung Neoplasms Clinical Biochemistry Cell non-small cell lung cancer (NSCLC) Motility MET Exon 14 Mutation 03 medical and health sciences 0302 clinical medicine Carcinoma Non-Small-Cell Lung Drug Discovery medicine Animals Humans Molecular Targeted Therapy Lung cancer Protein Kinase Inhibitors Gene Pharmacology business.industry Antibodies Monoclonal Proto-Oncogene Proteins c-met medicine.disease 030104 developmental biology medicine.anatomical_structure Apoptosis 030220 oncology & carcinogenesis Mutation Cancer research Molecular Medicine business Homeostasis
Zdroj:	Expert Opinion on Therapeutic Targets. 25:249-268
ISSN:	1744-7631 1472-8222
DOI:	10.1080/14728222.2021.1925648
Popis:	Introduction: The MET gene and its pathway normally plays a crucial role in cell homeostasis, motility, and apoptosis. However, when the MET gene is altered, there is an imbalance toward cell proli...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5c592a42dc7d57a452ee9ca95923925 https://doi.org/10.1080/14728222.2021.1925648 Zobrazit plný text záznamu