Immunopathogenesis of Severe Asthma
| Autor: | Yassine Amrani, Amanda Sutcliffe, Sunil Gupta, Fay Hollins, Christopher E. Brightling |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Pharmacology
medicine.medical_specialty business.industry Severe asthma Structure function macromolecular substances Disease medicine.disease Severity of Illness Index Asthma Drug Discovery Immunology medicine Airway Remodeling Animals Humans Mast Cells Intensive care medicine business Signal Transduction |
| Zdroj: | Current Pharmaceutical Design. 17:667-673 |
| ISSN: | 1381-6128 |
| Popis: | Severe asthma is a complex heterogeneous disease with substantial unmet clinical need. Understanding the immunopathogenesis is likely to provide insights into potential novel therapies. To date researchers have focussed primarily at a single scale for example genome, cell or whole organ physiology. In this review we shall summarise the current knowledge of the immunopathogenesis of severe asthma integrated across multiple scales to provide the insights into the structure function relationships required to begin to unravel the complexity of severe asthma. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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