Antimicrobial Susceptibilities of Oral Isolates of Abiotrophia and Granulicatella According to the Consensus Guidelines for Fastidious Bacteria
| Autor: | Shigemi Terakubo, Taisei Kanamoto, Hideki Nakashima |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Imipenem 030106 microbiology lcsh:Medicine Biology Article Microbiology Granulicatella elegans 03 medical and health sciences Ampicillin medicine polycyclic compounds General Environmental Science Abiotrophia defectiva nutritionally variant streptococci infective endocarditis lcsh:R General Engineering antimicrobial susceptibilities Abiotrophia Amoxicillin biochemical phenomena metabolism and nutrition biology.organism_classification bacterial infections and mycoses oral microbiota Penicillin stomatognathic diseases General Earth and Planetary Sciences Granulicatella medicine.drug |
| Zdroj: | Medicines Medicines, Vol 5, Iss 4, p 129 (2018) Volume 5 Issue 4 |
| ISSN: | 2305-6320 |
| Popis: | Background: The genera Abiotrophia and Granulicatella, previously known as nutritionally variant streptococci (NVS), are fastidious bacteria requiring vitamin B6 analogs for growth. They are members of human normal oral microbiota, and are supposed to be one of the important pathogens for so-called &ldquo culture-negative&rdquo endocarditis. Methods: The type strains and oral isolates identified, by using both phenotypic profiles and the DNA&ndash DNA hybridization method, were examined for susceptibilities to 15 antimicrobial agents including penicillin (benzylpenicillin, ampicillin, amoxicillin, and piperacillin), cephem (cefazolin, ceftazidime, ceftriaxone, and cefaclor), carbapenem (imipenem), aminoglycoside (gentamicin), macrolide (erythromycin), quinolone (ciprofloxacin), tetracycline (minocycline), glycopeptide (vancomycin), and trimethoprim-sulfamethoxazole complex. The minimum inhibitory concentration and susceptibility criterion were determined, according to the consensus guideline from the Clinical and Laboratory Standards Institute. Results: Isolates of Abiotrophia defectiva were susceptible to ampicillin, amoxicillin ceftriaxone, cefaclor, imipenem, ciprofloxacin, and vancomycin. Isolates of Granulicatella adiacens were mostly susceptible to benzylpenicillin, ampicillin, amoxicillin, cefazolin, ceftriaxone, imipenem, minocycline, and vancomycin. The susceptibility profile of Granulicatella elegans was similar to that of G. adiacens, and the susceptibility rate was higher than that of G. adiacens. Conclusions: Although Abiotrophia and Granulicatella strains are hardly distinguishable by their phenotypic characteristics, their susceptibility profiles to the antimicrobial agents were different among the species. Species-related differences in susceptibility of antibiotics should be considered in the clinical treatment for NVS related infections. |
| Databáze: | OpenAIRE |
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