Results and Outcome of Retroperitoneal Lymph Node Dissection for Clinical Stage I Embryonal Carcinoma–Predominant Testis Cancer
Autor: | Richard S. Foster, John P. Donohue, Christopher Sweeney, Benoit P. Hermans, Lawrence H. Einhorn, Douglas K. Heilman |
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Rok vydání: | 2000 |
Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Pathology medicine.medical_treatment Risk Assessment Gastroenterology Metastasis Embryonal carcinoma Retroperitoneal lymph node dissection Testicular Neoplasms Carcinoma Embryonal Internal medicine Antineoplastic Combined Chemotherapy Protocols Carcinoma medicine Humans Neoplasm Metastasis Stage (cooking) Testicular cancer Neoplasm Staging Retrospective Studies business.industry Incidence medicine.disease Treatment Outcome Oncology Chemotherapy Adjuvant Lymph Node Excision Lymphadenectomy Germ cell tumors Neoplasm Recurrence Local business |
Zdroj: | Journal of Clinical Oncology. 18:358-358 |
ISSN: | 1527-7755 0732-183X |
Popis: | PURPOSE: To determine the incidence of metastatic disease and usage of chemotherapy (adjuvant or metastatic) after primary retroperitoneal lymph node dissection (RPLND) in patients with clinical stage (CS) I embryonal carcinoma (EC)–predominant testicular cancer. EC predominance was defined as the presence of EC at a level greater than that of any other histologic diagonsis. PATIENTS AND METHODS: All CS I patients with nonseminomatous germ cell tumors who underwent RPLND at Indiana University from 1990 to 1995 were reviewed retrospectively. RESULTS: Two-year follow-up was available for 292 of 320 patients. EC-predominant disease was found in 125 (42.8%) of 292. Eighty-five (68.0%) of 125 patients with EC-predominant disease had pathologic stage (PS) I, and 18 (21.2%) of this group of 85 relapsed. A significantly lower PS I relapse rate of 3% was found for patients who had non–EC-predominant disease (P < .0001). PS II disease was more frequent in patients with EC predominance, as 40 (32.0%) of 125 had retroperitoneal metastases, compared with 26 (15.6%) of 167 patients with a non–EC-predominant histologic diagnosis (P = .0024). Chemotherapy was administered to 48 (38.4%) of the 125 patients with CS I EC-predominant disease after RPLND. This included 25 CS I patients with PS II disease who received adjuvant chemotherapy in addition to 23 patients who subsequently required chemotherapy for relapse after RPLND. Ten (66.6%) of 15 PS II EC-predominant patients were cured by surgery alone. Currently, all 125 EC-predominant patients are disease-free. CONCLUSION: Patients with CS I EC-predominant disease are at a relatively high risk for metastatic disease. |
Databáze: | OpenAIRE |
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