Cancer of unknown primary - incidence, mortality trend, and mortality-to-incidence ratio is associated with human development index in Central Serbia, 1999-2018: Evidence from the national cancer registry
| Autor: | Miodrag Stojanovic, Aleksandra Ignjatović, Dijana Stojanovic, Roberta Marković, Marija Topalović, Nataša Rančić, Tamara Filipović, Suzana Otašević, Marija Anđelković Apostolović, Zoran Milošević |
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| Rok vydání: | 2021 |
| Předmět: |
Male
03 medical and health sciences 0302 clinical medicine Life Expectancy Linear regression Medicine Humans 030212 general & internal medicine Registries business.industry Incidence (epidemiology) Mortality rate Incidence Confidence interval Annual Percent Change 3. Good health Cancer registry Trend analysis Oncology 030220 oncology & carcinogenesis Life expectancy Neoplasms Unknown Primary Female business Serbia Demography |
| Zdroj: | European journal of cancer careREFERENCES. 31(1) |
| ISSN: | 1365-2354 |
| Popis: | OBJECTIVES The aim was to estimate the trend of incidence, mortality and mortality-to-incidence ratio (MIR) in Central Serbia in 1999-2018 and its possible association with the human development index (HDI). METHODS In this study, cancer of unknown primary (CUP) was included as C77-C80 codes. Trend analysis was performed in the Joinpoint Regression Programme version 4.8.0.1. HDI combines life expectancy, educational attainment and gross national income. HDI values for Serbia are extracted from the global bank site. RESULTS Joinpoint regression analysis of the age-standardised incidence rate of CUP showed a significantly increasing trend with annual percent change (APC) of 8.5% (95% confidence interval [CI] 3.0-14.3%) in males and 7.8% (95%CI 2.7-13.2) in females. The age-standardised mortality rate of CUP showed a significantly decreasing trend with APC of -1.7% (95%CI -2.8 to -0.5%) in males and -1.4% (95%CI -2.7 to -0.1%) in females. MIR showed a significantly decreasing trend with APC of -9.3% (95%CI -14.6 - -3.6%) in males and -7.1% (95%CI -10.5% to -4.2%) in females. The linear regression showed significant inverse association among HDI and the MIR of CUP in males (r2 = 0.464, p = 0.002) and in females (r2 = 0.612, p |
| Databáze: | OpenAIRE |
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