| Autor: |
Atsushi Ochiai, Yuichiro Ohe, Kanji Nagai, Akio Niimi, Shinsuke Iida, Hironobu Ohmatsu, Shingo Matsumoto, Shigeki Umemura, Seiji Niho, Kiyotaka Yoh, Hiroko Hashimoto, Shinya Neri, Koichi Goto, Genichiro Ishii, Tatsuya Yoshida |
| Rok vydání: |
2023 |
| DOI: |
10.1158/1078-0432.22455117.v1 |
| Popis: |
Supplemental Figures 1-6. Supplemental Figure 1: Fluorescence microscopy showing mRFP-labeled PC-9 (red) and Venus-labeled CAFs (green) with or without gefitinib treatment. Supplemental Figure 2: mRNA levels of podoplanin (PDPN) in CAF-Ctrl and CAF PDPN-WT. Supplemental Figure 3: Co-culture with other CAFs induces gefitinib resistance. mRFP-labeled PC-9 and HCC-827 cells were co-cultured with CAFs (CAF-Ctrl, PDPN-WT, or CAF-PDPN-Del.IC) in the presence or absence of gefitinib treatment. The total cell numbers of PC-9 or HCC-827 cells treated for 72 hours with gefitinib in the presence or absence of Venus-labeled CAF-Ctrl, PDPN-WT, or CAF-PDPN-Del.IC are shown. Supplemental Figure 4: The number of the cases according to the PDPN-positive CAF area/stromal area (%). Supplemental Figure 5: PFS according to podoplanin expression in patients with EGFR common mutations (exon 19 deletion and L858R). Supplemental Figure 6: mRNA levels of HGF in CAF-Ctrl and CAF PDPN-WT. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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