Effect of prostaglandins on fatty acid metabolism in lung
| Autor: | Harvey S. Schiller, Richard K. Donabedian |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Chromatography
Gas Fatty Acids Nonesterified Cell Fractionation Biochemistry chemistry.chemical_compound Endocrinology Acetyl Coenzyme A Microsomes Animals Carbon Radioisotopes Lung Beta oxidation Phospholipids Triglycerides Fatty acid synthesis chemistry.chemical_classification Dose-Response Relationship Drug biology Fatty acid metabolism Fatty Acids Fatty acid Fatty acid synthase Cholesterol chemistry Depression Chemical Prostaglandins biology.protein Free fatty acid receptor Fatty acid elongation Female lipids (amino acids peptides and proteins) Chromatography Thin Layer Rabbits Beta-ketoacyl-ACP synthase Fatty Acid Synthases Acetyl-CoA Carboxylase |
| Zdroj: | Prostaglandins. 5:375-386 |
| ISSN: | 0090-6980 |
| DOI: | 10.1016/s0090-6980(74)80121-8 |
| Popis: | This is the first report of the effect of prostaglandins on the biochemical pathways for fatty acid synthesis. PGE2 and PGF2α inhibited fatty acid elongation in a lung microsomal fraction. Neither prostaglandin affected the de novo, or soluble, system for fatty acid synthesis (i.e. acetyl CoA carboxylase or fatty acid synthetase). The results also suggest that the initial inhibition of fatty acid synthesis leads to a decrease in free fatty acids available for esterification into phospholipids. The site and possible mechanisms of inhibition are discussed. |
| Databáze: | OpenAIRE |
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