Gestational diabetes mellitus is associated with increased CD163 expression and iron storage in the placenta
| Autor: | Jodell E. Linder, Hernan Correa, Jeffrey Adam Goldstein, Digna R. Velez-Edwards, Theresa L. Barke, Alexandra C. Sundermann, Arun P. Reddy, David M. Aronoff |
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| Rok vydání: | 2018 |
| Předmět: |
Meconium
0301 basic medicine endocrine system diseases Iron Placenta Immunology Antigens Differentiation Myelomonocytic Receptors Cell Surface 030209 endocrinology & metabolism Article Andrology 03 medical and health sciences 0302 clinical medicine Antigens CD Pregnancy Humans Immunology and Allergy Medicine Retrospective Studies Amnion business.industry CD68 Macrophages Decidua nutritional and metabolic diseases Obstetrics and Gynecology Gestational age Histology medicine.disease female genital diseases and pregnancy complications Gestational diabetes Diabetes Gestational 030104 developmental biology medicine.anatomical_structure Hematocrit Reproductive Medicine Case-Control Studies embryonic structures Female business CD163 |
| Zdroj: | American Journal of Reproductive Immunology. 80:e13020 |
| ISSN: | 1046-7408 |
| DOI: | 10.1111/aji.13020 |
| Popis: | Problem GDM has been associated with disturbances in iron homeostasis and exaggerated immune activation. We sought to investigate the extent to which placental iron storage and macrophage accumulations were altered in GDM. Method of study We conducted a retrospective, case-control study of archived placental tissues obtained from 22 pregnancies complicated by GDM and 22 unaffected controls. Controls were matched to cases based on maternal age, gestational age at birth, and method of delivery. Placental tissues were assessed for altered histology and CD68 and CD163 staining. Tissue iron was assessed using Prussian blue staining. Results Maternal hematocrit levels were higher in GDM participants compared to controls (P = 0.02). The presence of meconium-laden macrophages was significantly greater within the amnion of GDM cases (adjusted odds ratio (OR) 12.51). Although the total abundance of CD68-expressing macrophages was not significantly different between groups, we detected a significantly greater abundance of CD163 expression within the chorion and decidua of cases. The total area staining positive for iron was 24% (95% confidence intervals of 2%-46%) greater in GDM placentae versus controls. Conclusion GDM is associated with altered placental histology and increases in meconium-laden macrophages. Greater iron stores within the placentae of women with GDM is consistent with reports that iron excess is associated with an increased risk for GDM. The higher level of expression of CD163 on macrophage-like cells of the chorion and decidua in GDM suggests an increase in M2-like macrophages. Overall, our results add to growing evidence that GDM has direct effects on placental structure. |
| Databáze: | OpenAIRE |
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