Outcomes of catheter ablation of atrial fibrillation in patients with hypertrophic cardiomyopathy: a systematic review and meta-analysis
| Autor: | Yi Hua Lu, Hui He Lu, Lin Sheng Shi, Bang Tao Chen, Yi Shen, Dong-Sheng Zhao, Jianfei Huang, Qing Zhang, Gang Lin |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Reoperation medicine.medical_specialty Cardiac Catheterization Time Factors medicine.medical_treatment Catheter ablation Kaplan-Meier Estimate 030204 cardiovascular system & hematology Disease-Free Survival 03 medical and health sciences 0302 clinical medicine Recurrence Risk Factors Physiology (medical) Internal medicine Atrial Fibrillation medicine Humans Sinus rhythm 030212 general & internal medicine Cardiac catheterization Aged business.industry Incidence (epidemiology) Hypertrophic cardiomyopathy Atrial fibrillation Cardiomyopathy Hypertrophic Middle Aged medicine.disease Confidence interval Treatment Outcome Meta-analysis Cardiology Female Cardiology and Cardiovascular Medicine business Anti-Arrhythmia Agents |
| Zdroj: | Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. 18(4) |
| ISSN: | 1532-2092 |
| Popis: | Aims Over the past decade, catheter ablation (CA) has become an established therapy for symptomatic atrial fibrillation (AF). Atrial fibrillation is common in hypertrophic cardiomyopathy (HCM) patients, and restoring sinus rhythm is of great clinical benefit to them. Therefore, we conducted a systematic review and meta-analysis of the available data to evaluate the effectiveness and safety of CA for AF in patients with HCM. Methods and Results Six databases were searched to identify studies describing outcomes of CA of AF in HCM patients with a mean follow-up of ≥12 months after the index procedure. The following data were extracted: (i) single-procedure success, (ii) multiple-procedure success, and (iii) drug-free success. Fifteen studies involving 531 patients were included. Single-procedure freedom from atrial arrhythmia at the latest follow-up was 45.5% [95% confidence interval (CI): 34.8–56.2%]. With multiple procedures, the final success rate was 66.1% (95% CI: 55.3–76.9%) overall, 71.8% (95% CI: 61.6–82.0%) in paroxysmal AF, and 47.5% (95% CI: 36.0–59.0%) in non-paroxysmal AF. Without anti-arrhythmic drugs (AADs), single-procedure success rate at latest follow-up was 32.9% (95% CI: 21.7–41.1%); after multiple procedures, this raised to 50.4% (95% CI: 39.2–61.6%). The incidence of serious periprocedural complications was acceptable [5.1% (95% CI: 2.8–9.6%)]. Substantial heterogeneity ( I 2> 50%) was noted in the above groups. Conclusions Catheter ablation of AF in patients with HCM is feasible, although more repeat procedures and AAD are needed to prevent AF recurrence. |
| Databáze: | OpenAIRE |
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