Qualitative and Quantitative Study of the Potential of Lipid Nanocapsules of One Hundred Twenty Nanometers for the Topical Administration of Hydrophobic Molecules

Autor: Thomas Perrier, Emilie Munnier, Xavier Perse, Martin Soucé, Francis Vial, Igor Chourpa, Florent Yvergnaux, Hoang Truc Phuong Nguyen
Přispěvatelé: Nanomédicaments et Nanosondes, EA 6295 (NMNS), Université de Tours (UT), Spincontrol France, Tours, France, Bioeurope Groupe Solabia, Ingénierie de la vectorisation particulaire, Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Carlina Technologies, Angers, France, Université de Tours
Rok vydání: 2016
Předmět:
skin
Cell Survival
Swine
Stereochemistry
Administration
Topical
Skin Absorption
Pharmaceutical Science
Human skin
02 engineering and technology
010402 general chemistry
01 natural sciences
Nanocapsules
chemistry.chemical_compound
Drug Delivery Systems
Organ Culture Techniques
[CHIM.ANAL]Chemical Sciences/Analytical chemistry
Stratum corneum
medicine
Animals
Humans
curcumin
Transdermal
Dose-Response Relationship
Drug
integumentary system
Chemistry
Penetration (firestop)
fluorescence confocal spectral imaging
021001 nanoscience & nanotechnology
Lipids
nanomedicine
3. Good health
0104 chemical sciences
[SDV.SP.PG]Life Sciences [q-bio]/Pharmaceutical sciences/Galenic pharmacology
medicine.anatomical_structure
drug delivery
Drug delivery
Curcumin
Biophysics
Nanocarriers
0210 nano-technology
Hydrophobic and Hydrophilic Interactions
Zdroj: Journal of Pharmaceutical Sciences-Elsevier
Journal of Pharmaceutical Sciences-Elsevier, Elsevier, 2016, 105 (10), pp.3191-3198. ⟨10.1016/j.xphs.2016.06.025⟩
ISSN: 0022-3549
DOI: 10.1016/j.xphs.2016.06.025
Popis: International audience; In this study, we evaluated the potential of lipid nanocapsules (LNC) of 120 nm as drug nanocarriers to treat skin diseases. As a model molecule, we encapsulated the fluorescent dye curcumin, which also is an antioxidant. Curcumin-loaded LNC showed interesting antioxidant properties and a low toxicity on human skin cells. The penetration of curcumin in the skin was determined by 2 complementary methods: high performance liquid chromatography was used to measure total curcumin accumulation in the skin, whereas fluorescence confocal spectral imaging of skin sections showed that curcumin preferentially accumulates in the stratum corneum and the viable epidermis. These results confirm that LNC of a size above 100 nm can vectorize hydrophobic compounds to the keratinocytes without transdermal delivery. They also demonstrate the interest of combining 2 analytical methods when studying the skin penetration of nanovectorized molecules.
Databáze: OpenAIRE
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