Molecular epidemiology and clinical characteristics of norovirus gastroenteritis with seizures in children in Taiwan, 2006–2015
| Autor: | Shu Sing Kong, Ying Fang Elaine Chen, Chuan Yu Wang, Shih Yen Chen, Cheng-Hsun Chiu, Yi Jung Chang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Fever Genotype Taiwan Observational Study norovirus Disease medicine.disease_cause 03 medical and health sciences 0302 clinical medicine children Seizures Internal medicine Medicine Humans 030212 general & internal medicine Child Genotyping Caliciviridae Infections Retrospective Studies Molecular Epidemiology Molecular epidemiology business.industry Reverse Transcriptase Polymerase Chain Reaction Infant General Medicine Sequence Analysis DNA medicine.disease Gastroenteritis 030220 oncology & carcinogenesis Child Preschool Norovirus Vomiting Encephalitis RNA Viral Female Seasons medicine.symptom business Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 0025-7974 |
| Popis: | This study examined the characteristics of norovirus (NoV) gastroenteritis associated with convulsions in children and its molecular epidemiology. From July 2006 through December 2015, NoV infection was confirmed by the genome detection using reverse transcriptase polymerase chain reaction. Viral genotyping with strain validation was achieved using sequence analyses with Basic Local Alignment Search Tool genome identification. The patients’ clinical features were assessed retrospectively, focusing on convulsive disorders. The diagnosis of encephalitis followed the International Encephalitis Consortium. Seizures occurred in 52 (20.9%) of 249 NoV infections. GII.4 Den_Haag_2006b (n = 22, 42.3%) and GII.4 Sydney 2012 (n = 10, 19.2%) were major variants correlated with convulsions. Patient with convulsions tend to have GII.4 genotype infection (P |
| Databáze: | OpenAIRE |
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