Rational Vaccine Design in Times of Emerging Diseases: The Critical Choices of Immunological Correlates of Protection, Vaccine Antigen and Immunomodulation
| Autor: | Alla Zamyatina, Antonio Molinaro, Cristina Nativi, Alberto Fernández-Tejada, Ihsan Gursel, Aneesh Thakur, Carmen Alvarez-Dominguez, Siobhán McClean, Peter van der Ley, Artur Summerfield, Camillo Rosano, Dragomira Majhen, Virgil E.J.C. Schijns, Sveinbjörn Gizurarson, Žiga Jakopin, Rita Berisio |
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| Přispěvatelé: | Gürsel, İhsan |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
rational
vaccine design antigen adjuvant delivery system route immunization Design medicine.medical_treatment T cell lcsh:RS1-441 Pharmaceutical Science 610 Medicine & health Review Vaccine antigen lcsh:Pharmacy and materia medica 03 medical and health sciences 0302 clinical medicine Immune system Antigen Vaccine adjuvant medicine 030212 general & internal medicine Biology Adjuvant Delivery system 030304 developmental biology 0303 health sciences 630 Agriculture business.industry Route Rational design food and beverages Rational medicine.anatomical_structure Immunization Immunology 570 Life sciences biology business Vaccine |
| Zdroj: | Schijns, Virgil; Majhen, Dragomira; van der Ley, Peter; Thakur, Aneesh; Summerfield, Artur; Berisio, Rita; Nativi, Cristina; Fernández-Tejada, Alberto; Alvarez-Dominguez, Carmen; Gizurarson, Sveinbjörn; Zamyatina, Alla; Molinaro, Antonio; Rosano, Camillo; Jakopin, Žiga; Gursel, Ihsan; McClean, Siobhán (2021). Rational Vaccine Design in Times of Emerging Diseases: The Critical Choices of Immunological Correlates of Protection, Vaccine Antigen and Immunomodulation. Pharmaceutics, 13(4) MDPI 10.3390/pharmaceutics13040501 Pharmaceutics Pharmaceutics, Vol 13, Iss 501, p 501 (2021) Schijns, V, Majhen, D, Van Der Ley, P, Thakur, A, Summerfield, A, Berisio, R, Nativi, C, Fernández-tejada, A, Álverez-dominguez, C, Gizurarson, S, Zamyatina, A, Molinaro, A, Rosano, C, Jakopin, Ž, Gursel, I & Mcclean, S 2021, ' Rational Vaccine Design in Times of Emerging Diseases: The Critical Choices of Immunological Correlates of Protection, Vaccine Antigen and Immunomodulation ', Pharmaceutics, vol. 13, no. 4, 501 . https://doi.org/10.3390/pharmaceutics13040501 |
| DOI: | 10.3390/pharmaceutics13040501 |
| Popis: | Vaccines are the most effective medical intervention due to their continual success in preventing infections and improving mortality worldwide. Early vaccines were developed empirically however, rational design of vaccines can allow us to optimise their efficacy, by tailoring the immune response. Establishing the immune correlates of protection greatly informs the rational design of vaccines. This facilitates the selection of the best vaccine antigens and the most appropriate vaccine adjuvant to generate optimal memory immune T cell and B cell responses. This review outlines the range of vaccine types that are currently authorised and those under development. We outline the optimal immunological correlates of protection that can be targeted. Finally we review approaches to rational antigen selection and rational vaccine adjuvant design. Harnessing current knowledge on protective immune responses in combination with critical vaccine components is imperative to the prevention of future life-threatening diseases. |
| Databáze: | OpenAIRE |
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