Two-Week Isocaloric Time-Restricted Feeding Decreases Liver Inflammation without Significant Weight Loss in Obese Mice with Non-Alcoholic Fatty Liver Disease

Autor:	Rachel B. Wilson, Krisha Patel, René L. Jacobs, John P. Kennelly, Yun Jin Chen, Rennian Wang, Cynthia G. Sawyez, Kelly-Ann Leonard, Kia M. Peters, Nica M. Borradaile, Brian G. Sutherland, Richard Zhang
Rok vydání:	2020
Předmět:	Blood Glucose 0301 basic medicine obesity Mouse Biopsy Hepatitis lcsh:Chemistry Mice 0302 clinical medicine Non-alcoholic Fatty Liver Disease Weight loss Glucose homeostasis lcsh:QH301-705.5 Endoplasmic Reticulum Chaperone BiP Spectroscopy Fatty liver Fasting General Medicine Computer Science Applications Liver medicine.symptom TXNIP medicine.medical_specialty 030209 endocrinology & metabolism Inflammation liver Article Catalysis Inorganic Chemistry 03 medical and health sciences NAFLD Internal medicine medicine Animals Obesity Physical and Theoretical Chemistry Molecular Biology mouse business.industry Gene Expression Profiling Body Weight Organic Chemistry Lipid Metabolism medicine.disease Disease Models Animal Glucose 030104 developmental biology Endocrinology lcsh:Biology (General) lcsh:QD1-999 inflammation Steatosis Metabolic syndrome business Biomarkers
Zdroj:	Paediatrics Publications International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 21, Iss 9156, p 9156 (2020) Volume 21 Issue 23
ISSN:	1422-0067
DOI:	10.3390/ijms21239156
Popis:	Prolonged, isocaloric, time-restricted feeding (TRF) protocols can promote weight loss, improve metabolic dysregulation, and mitigate non-alcoholic fatty liver disease (NAFLD). In addition, 3-day, severe caloric restriction can improve liver metabolism and glucose homeostasis prior to significant weight loss. Thus, we hypothesized that short-term, isocaloric TRF would improve NAFLD and characteristics of metabolic syndrome in diet-induced obese male mice. After 26 weeks of ad libitum access to western diet, mice either continued feeding ad libitum or were provided with access to the same quantity of western diet for 8 h daily, over the course of two weeks. Remarkably, this short-term TRF protocol modestly decreased liver tissue inflammation in the absence of changes in body weight or epidydimal fat mass. There were no changes in hepatic lipid accumulation or other characteristics of NAFLD. We observed no changes in liver lipid metabolism-related gene expression, despite increased plasma free fatty acids and decreased plasma triglycerides in the TRF group. However, liver Grp78 and Txnip expression were decreased with TRF suggesting hepatic endoplasmic reticulum (ER) stress and activation of inflammatory pathways may have been diminished. We conclude that two-week, isocaloric TRF can potentially decrease liver inflammation, without significant weight loss or reductions in hepatic steatosis, in obese mice with NAFLD.
Databáze:	OpenAIRE
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