Outpatient Use of Antimicrobials in Patients With Rheumatoid Arthritis Before and After Treatment With Tumor Necrosis Factor Inhibitors: A Nationwide Retrospective Cohort Study
| Autor: | Mar Kristjansson, Icebio, Gerdur Gröndal, Bjorn Gudbjornsson, Thorvardur Jon Love, Aron H. Bjornsson, Olafur Petur Palsson, Pétur Gunnarsson |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
education.field_of_study medicine.drug_class business.industry Antibiotics Population Retrospective cohort study Diseases of the musculoskeletal system Antimicrobial medicine.disease Rheumatology RC925-935 Internal medicine Rheumatoid arthritis medicine Tumor necrosis factor alpha Medical prescription education business Body mass index |
| Zdroj: | ACR Open Rheumatology, Vol 4, Iss 2, Pp 187-194 (2022) |
| ISSN: | 2578-5745 |
| Popis: | OBJECTIVE The objective of this study was to investigate the effect of tumor necrosis factor α inhibitor (TNFi) initiation on the use of antimicrobials among biologic-naive patients with rheumatoid arthritis (RA). METHODS Information on all biologic-naive patients with RA was extracted from ICEBIO, a nationwide registry. Each patient was matched on age, sex, and calendar time to five randomly selected individuals from the general population. All filled antimicrobial and glucocorticoid prescriptions in the 2 years before and after initiation of the first TNFi were extracted from the Prescription Medicines Register. Prescriptions were quantified by using the number of filled prescriptions (NP) and defined daily doses. RESULTS We extracted information on 359 patients with RA and 1795 comparators. During the 24 months before initiating treatment with TNFi, patients with RA received more prescriptions for antimicrobials than their matched general population comparators (mean ± SD: 2.8 ± 3.4 vs 1.6 ± 2.7; P |
| Databáze: | OpenAIRE |
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