Ivabradine in combination with beta-blocker therapy for the treatment of stable angina pectoris in every day clinical practice
| Autor: | Henning Ebelt, Ralf Koester, Gerold Soeffker, Karl Werdan, Jan Kaehler, Thomas Meinertz |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Bradycardia medicine.medical_specialty Nausea Adrenergic beta-Antagonists Angina Pectoris Angina Coronary artery disease Pharmacotherapy Membrane Transport Modulators Internal medicine Heart rate medicine Humans Ivabradine Aged business.industry General Medicine Benzazepines Middle Aged medicine.disease Clinical trial Treatment Outcome Cardiology Drug Therapy Combination Female medicine.symptom Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Clinical Research in Cardiology. 99:665-672 |
| ISSN: | 1861-0692 1861-0684 |
| DOI: | 10.1007/s00392-010-0172-4 |
| Popis: | The anti-anginal efficacy of the selective If inhibitor ivabradine has been demonstrated in controlled clinical trials. However, there is limited information about the safety and efficacy of a combined treatment of ivabradine with beta-blockers, particularly outside of clinical trials in every day practice. This analysis from the REDUCTION study evaluated the safety and efficacy of a combined therapy of beta-blockers and ivabradine in every day practice. In this multi-center study 4,954 patients with stable angina pectoris were treated with ivabradine in every day routine practice and underwent a clinical follow-up for 4 months. 344 of these patients received a co-medication with beta-blockers. Heart rate (HR), angina pectoris episodes, nitrate consumption, overall efficacy and tolerance were analyzed. After 4 months of treatment with ivabradine HR was reduced by 12.4 ± 11.6 bpm from 84.3 ± 14.6 to 72.0 ± 9.9 bpm, p |
| Databáze: | OpenAIRE |
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