Evaluation of treatment-associated eye toxicity after irradiation in childhood and adolescence—results from the Registry of the Evaluation of Side Effects after Radiotherapy in Childhood and Adolescence (RiSK)
| Autor: | Hans Theodor Eich, Normann Willich, Fenja Albrecht, Yvonne Ziert, Christiane Matuschek, Christian Rübe, Rolf-Dieter Kortmann, Diana Steinmann, Hans Christiansen, Beate Timmermann, Carmen Martini, Heidi Wolters |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Multivariate analysis Adolescent medicine.medical_treatment Medizin High radiation Eye 030218 nuclear medicine & medical imaging Late toxicity Young Adult 03 medical and health sciences Eye Injuries 0302 clinical medicine Patient age Humans Medicine Radiology Nuclear Medicine and imaging Registries Side effects Child Radiation Injuries Radiation Radiotherapy business.industry Infant Radiotherapy Dosage Childhood Acute toxicity Ocular toxicity Radiation therapy Oncology Child Preschool 030220 oncology & carcinogenesis Toxicity Original Article Female business |
| Zdroj: | Strahlentherapie Und Onkologie |
| ISSN: | 1439-099X 0179-7158 |
| DOI: | 10.1007/s00066-021-01793-2 |
| Popis: | Purpose The aim of the study is to evaluate treatment-related acute and late eye toxicity associated with radiation therapy in childhood and adolescence as correlated with RT (radiotherapy) doses. Methods From 2001 to 2016, a total of 1725 children and adolescents undergoing radiation therapy were prospectively documented in the Registry of the Evaluation of Side Effects after Radiotherapy in Childhood and Adolescence (RiSK). The RTOG/EORTC criteria were used to classify ocular acute and late effects. Uni- and multivariate analyses were carried out to evaluate the impact of patient age, pre-existing impairments, and radiation dose on ocular toxicity. Results Of all documented patients, 593 received dose to the eye and formed the basis of this analysis. In 435 patients, information on acute reaction was available and graded 1, 2, 3, and 4 in 49, 17, 0, and 2 patients, respectively. Information on late toxicity was available in 268 patients and graded 1, 2, 3, and 4 in 15, 11, 11, and 5 patients, respectively. The acute toxicity rate was significantly higher in children who received a maximum dose > 50 Gy to the eye (p p 50 Gy. Conclusion Acute and late toxicity both correlate with high radiation dose to the eye (> 50 Gy) and acute toxicity additionally with pre-existing eye impairments. |
| Databáze: | OpenAIRE |
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