Iron overload in children receiving prolonged parenteral nutrition
| Autor: | Caroline Rambaud, Odile Corriol, Virginie Colomb, M. Ben Hariz, Claude Ricour, M. Girot, O. Goulet, S. De Potter |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
medicine.medical_specialty
Time Factors Adolescent Biopsy Iron Gastroenterology Internal medicine Humans Medicine Child chemistry.chemical_classification biology medicine.diagnostic_test business.industry Transferrin saturation Transferrin Infant Alanine Transaminase Surgery Ferritin Parenteral nutrition Liver Alanine transaminase chemistry Child Preschool Liver biopsy Ferritins Pediatrics Perinatology and Child Health biology.protein Serum iron Parenteral Nutrition Total business |
| Zdroj: | The Journal of Pediatrics. 123:238-241 |
| ISSN: | 0022-3476 |
| DOI: | 10.1016/s0022-3476(05)81694-4 |
| Popis: | This study was carried out to evaluate the iron status of 30 children aged 1 to 18 years who had been receiving total parenteral nutrition (TPN) for an average of 43 months with iron intakes of 100 micrograms/kg per day. Iron status was assessed by assaying the serum iron and ferritin levels and the transferrin saturation coefficient as a function of iron intake. Liver biopsy specimens were taken from 13 children. Twelve children had serum ferritin levels greater than 300 ng/ml, and 8 had levels greater than 800 ng/ml. The serum ferritin level and the transferrin saturation coefficient were positively correlated (r = 0.81; p0.01). The serum ferritin level was positively correlated with TPN duration and with the total iron intake (r = 0.68; p0.01). Of the 13 liver biopsy specimens, six showed signs of iron deposition. We conclude that there is a risk of iron overload in children receiving 100 micrograms iron per kilogram of body weight per day by TPN, indicating that intake should be reduced. |
| Databáze: | OpenAIRE |
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