Relationships of ATP to fatty liver: effects of adenine analogue, 4-aminopyrazolopyrimidine on lipid metabolism in rat liver
| Autor: | Paolo Emilio Puddu, Mario Marchetti, Vittoria Ottani, Paola Zanetti |
|---|---|
| Rok vydání: | 1970 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism Biology Acetates Glucosephosphate Dehydrogenase In Vitro Techniques chemistry.chemical_compound Endocrinology Adenosine Triphosphate Internal medicine mental disorders medicine Animals Nucleotide chemistry.chemical_classification Carbon Isotopes Nicotinamide Phosphogluconate Dehydrogenase Atp content Fatty liver Lipid metabolism medicine.disease Lipid Metabolism NAD Lipids In vitro Stimulation Chemical Rats Fatty Liver Pyrimidines Biochemistry chemistry Liver Rat liver Lipogenesis Pyrazoles Female NADP |
| Zdroj: | Metabolism: clinical and experimental. 19(2) |
| ISSN: | 0026-0495 |
| Popis: | The effects of 4-aminopyrazolopyrimidine (APP) on lipid content, on lipogenesis and on ATP and nicotinamide nucleotide levels in the liver of rats were studied at various time intervals after injection of APP. Treatment with APP caused a maximal increase of total liver lipids within 16 hours following injection together with a decrease of incorporation of 1- 14 C-acetate into lipids in vitro. Liver ATP content, after a temporary enhancement, was rapidly decreased by the administration of APP; a large decrease in NADH and NADPH resulted. The relationships between the onset of fatty liver, ATP and nicotinamide nucleotide concentration in the liver of APP-treated animals are discussed. |
| Databáze: | OpenAIRE |
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