Association between interleukin-10-819T/C polymorphism and risk of ischemic stroke: A meta-analysis
| Autor: | Haishan Li, Tingting Zheng, Shuang Zuo |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Population Gastroenterology Polymorphism Single Nucleotide Brain Ischemia polymorphism 03 medical and health sciences 0302 clinical medicine Internal medicine Genetic model medicine ischemic stroke Humans Genetic Predisposition to Disease 030212 general & internal medicine education education.field_of_study business.industry General Medicine Odds ratio Confidence interval Interleukin-10 Stroke meta-analysis Interleukin 10 interleukin-10-819T/C Sample size determination 030220 oncology & carcinogenesis Meta-analysis Ischemic stroke business Systematic Review and Meta-Analysis Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 |
| Popis: | Background: The interleukin-10 (IL-10)-819T/C polymorphism has been indicated to be correlated with ischemic stroke susceptibility, but this relationship remains controversial. A meta-analysis was conducted to investigate the potential association between IL-10-819T/C polymorphism and ischemic stroke risk. Methods: Databases including Pubmed, Embase, and CNKI were searched. Data were extracted and odds ratios (OR) with 95% confidence intervals (CI) were calculated. Results: Eight case-control studies with 1832 cases and 1520 controls were included in this meta-analysis. IL-10-819T/C polymorphism may decrease the risk of ischemic stroke (C vs T: OR = 1.01, 95% CI: 0.91–1.12; CC vs TT: OR = 0.91, 95% CI: 0.73–1.14; CT vs TT: OR = 1.10, 95% CI: 0.95–1.28; CC + CT vs TT: OR = 1.06, 95% CI: 0.92–1.22; CC vs CT + TT: OR = 0.91, 95% CI: 0.75–1.11). In the stratified analysis by sample size, and case-control matched status, significant associations were still not observed in all genetic models. In the subgroup meta-analysis based on source of controls, IL-10-819T/C polymorphism had decreased ischemic stroke risk for recessive model in population-based controls’ subgroup (CC vs CT + TT: OR = 0.69, 95% CI: 0.50–0.95), but not in the hospital-based controls’ subgroup. In the stratified analysis based on ethnicity, IL-10-819T/C polymorphism had decreased ischemic stroke risk for recessive model in Asian populations (CC vs CT + TT: OR = 0.78, 95% CI: 0.62–0.99), but not in Caucasian populations. Conclusions: In conclusion, the results suggest that the IL-10-819T/C polymorphism is not associated with ischemic stroke risk. Larger scale studies are needed for confirmation. |
| Databáze: | OpenAIRE |
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