E2F-1, Skp2 and cyclin E oncoproteins are upregulated and directly correlated in high-grade neuroendocrine lung tumors
| Autor: | Beatrice Eymin, G. Merdzhanova, Elisabeth Brambilla, Caroline Salon, Christian Brambilla, Sylvie Gazzeri |
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| Přispěvatelé: | Institut d'oncologie/développement Albert Bonniot de Grenoble (INSERM U823), Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), INSERM U823, équipe 2 (Bases Moléculaires de la Progression des Cancers du Poumon), Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), Eq 2 - Bases Moléculaires de la Progression des Cancers du Poumon [La Tronche] (Inserm U823/UJF/Institut Albert Bonniot), This work was supported by grants from the Region Rhône Alpes (Thématique Prioritaire Cancer and Canceropole 2003: Oncocell, Epimed and INACancer) and by the Ligue Nationale contre le Cancer (Equipe Labellisée). C.S. was supported by a 'poste accueil' INSERM., Eymin, Beatrice, Equipe 2 - Bases Moléculaires de la Progression des Cancers du Poumon, Inserm U823, Salas, Danielle |
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Cancer Research
Lung Neoplasms Cyclin E Transcription Genetic [SDV]Life Sciences [q-bio] MESH: Lymphatic Metastasis medicine.disease_cause Immunoenzyme Techniques 0302 clinical medicine MESH: Reverse Transcriptase Polymerase Chain Reaction MESH: RNA Small Interfering MESH: Up-Regulation RNA Small Interfering S-Phase Kinase-Associated Proteins Oncogene Proteins 0303 health sciences MESH: Immunoblotting Reverse Transcriptase Polymerase Chain Reaction MESH: Carcinoma Squamous Cell MESH: Neoplasm Staging Up-Regulation 3. Good health [SDV] Life Sciences [q-bio] MESH: E2F1 Transcription Factor Neuroendocrine Tumors Lymphatic Metastasis 030220 oncology & carcinogenesis Carcinoma Squamous Cell Immunohistochemistry Skp2 MESH: S-Phase Kinase-Associated Proteins MESH: Neuroendocrine Tumors Immunoblotting E2F-1 [SDV.CAN]Life Sciences [q-bio]/Cancer [SDV.BC]Life Sciences [q-bio]/Cellular Biology Biology 03 medical and health sciences MESH: Oncogene Proteins [SDV.CAN] Life Sciences [q-bio]/Cancer Downregulation and upregulation Biomarkers Tumor Genetics SKP2 medicine Humans Immunoprecipitation E2F MESH: Immunoenzyme Techniques [SDV.BC] Life Sciences [q-bio]/Cellular Biology Molecular Biology Transcription factor Neoplasm Staging 030304 developmental biology MESH: Humans Cell growth MESH: Immunoprecipitation MESH: Transcription Genetic MESH: Cyclin E MESH: Lung Neoplasms MESH: Tumor Markers Biological Cancer research lung tumors Carcinogenesis E2F1 Transcription Factor |
| Zdroj: | Oncogene Oncogene, Nature Publishing Group, 2007, 26 (48), pp.6927-36. ⟨10.1038/sj.onc.1210499⟩ Oncogene, Nature Publishing Group, 2007, 26 (48), pp.6927-6936. ⟨10.1038/sj.onc.1210499⟩ |
| ISSN: | 0950-9232 1476-5594 |
| DOI: | 10.1038/sj.onc.1210499⟩ |
| Popis: | International audience; The transcription factor E2F-1 plays a crucial role in the control of cellular growth. We previously reported its differential pattern of expression in human lung tumors. In this study, we have investigated the relationships linking the status of E2F-1 and a mediator of its proteasomal degradation, the S-phase kinase-associated protein 2 (Skp2) F-box protein. Using immunohistochemistry in a series of 129 lung tumors of all histological types, we demonstrate that Skp2 accumulates preferentially in high-grade neuroendocrine (HGNE) lung carcinomas (86%, P |
| Databáze: | OpenAIRE |
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