RAD52 Y415X truncation polymorphism and epithelial ovarian cancer risk in Australian women
| Autor: | David M. Purdie, Livia Kelemen, Dorota M. Gertig, Georgia Chenevix-Trench, Amanda B. Spurdle |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Cancer Research Genotype RAD52 Biology Risk Factors medicine Humans Epithelial ovarian cancer Neoplasms Glandular and Epithelial Gene Aged Aged 80 and over Ovarian Neoplasms Polymorphism Genetic Heterozygote advantage Middle Aged medicine.disease Rad52 DNA Repair and Recombination Protein Risk Estimate Oncology Cancer research Female Homologous recombination Ovarian cancer RAD52 Gene |
| Zdroj: | Cancer letters. 218(2) |
| ISSN: | 1872-7980 |
| Popis: | The RAD52 gene is involved in the homologous recombination repair pathway and is a plausible candidate ovarian cancer predisposition gene. We undertook a case-control comparison of 508 epithelial ovarian cancer cases (91 low malignant potential and 417 invasive) and 298 healthy controls to assess the RAD52 Y415X polymorphism as a risk factor for epithelial ovarian cancer in Australian women. Heterozygote frequencies of 2.6 and 4% were observed among cases and controls, respectively. The risk estimate was 0.55 (95%CI 0.24-1.24), suggesting that the RAD52 Y415X polymorphism is not associated with epithelial ovarian cancer in Australian women. (C) 2004 Elsevier Ireland Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect