Microwave-Assisted Pd/Cu-Catalyzed C-8 Direct Alkenylation of Purines and Related Azoles An Alternative Access to 6,8,9-Trisubstituted Purines
| Autor: | Sandrine Piguel, Roxane Vabre, Michel Legraverend, Franciane Chevot |
|---|---|
| Přispěvatelé: | Conception, synthèse et vectorisation de biomolécules. (CSVB), Institut Curie-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5), Université Paris Descartes - Paris 5 (UPD5)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut Curie [Paris], Marie, Nathalie |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Azoles
chemistry.chemical_element 010402 general chemistry 01 natural sciences Microwave assisted Catalysis chemistry.chemical_compound Nucleophilic substitution Purine metabolism Microwaves ComputingMilieux_MISCELLANEOUS Molecular Structure 010405 organic chemistry [CHIM.ORGA]Chemical Sciences/Organic chemistry Organic Chemistry Regioselectivity Stereoisomerism [CHIM.ORGA] Chemical Sciences/Organic chemistry Copper Combinatorial chemistry 0104 chemical sciences chemistry Purines Functional group Palladium |
| Zdroj: | Journal of Organic Chemistry Journal of Organic Chemistry, American Chemical Society, 2011, pp.9542-9547 |
| ISSN: | 0022-3263 1520-6904 |
| Popis: | An efficient microwave-assisted palladium/copper comediated C-8 direct alkenylation of purines with styryl bromides has been developed. The method is regioselective, functional group tolerant, rapid, and compatible with other related azoles. Combined with subsequent nucleophilic substitution, it provides an easy access to new 6,8,9-trisubstituted purines. |
| Databáze: | OpenAIRE |
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