Nicotine and amphetamine: Differential tolerance and no cross-tolerance for Ingestive effects
| Autor: | Karl Baettig, James R. Martin, Werner Classen |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Male
Nicotine medicine.medical_specialty Clinical Biochemistry Anorexia Toxicology Body weight Biochemistry Eating Behavioral Neuroscience Weight loss Drug tolerance Internal medicine medicine Animals Amphetamine Biological Psychiatry Pharmacology business.industry Body Weight Hypodipsia Drug Tolerance Rats Cross-tolerance Endocrinology medicine.symptom business medicine.drug |
| Zdroj: | Pharmacology Biochemistry and Behavior. 12:107-111 |
| ISSN: | 0091-3057 |
| Popis: | Rats chronically treated twice daily with nicotine (0.4 mg/kg, SC) or d,1-amphetamine (1.5 mg/kg, SC) exhibited different patterns of anorexia, hypodipsia, and body weight loss. Amphetamine-treated rats developed tolerance to these ingestive effects and to weight loss, whereas nicotine-injected rats did not. There was little, if any, evidence for cross-tolerance when the drugs were switched between the two groups. These results indicate that different mechanisms underlie the ingestive effects of nicotine and amphetamine. |
| Databáze: | OpenAIRE |
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