Height and Body Mass Index as Modifiers of Breast Cancer Risk in BRCA1/2 Mutation Carriers: A Mendelian Randomization Study
| Autor: | Qian, F., Wang, S.F., Mitchell, J., McGuffog, L., Barrowdale, D., Leslie, G., Oosterwijk, J.C., Chung, W.K., Evans, D.G., Engel, C., Kast, K., Aalfs, C.M., Adank, M.A., Adlard, J., Agnarsson, B.A., Aittomaki, K., Alducci, E., Andrulis, I.L., Arun, B.K., Ausems, M.G.E.M., Azzollini, J., Barouk-Simonet, E., Barwell, J., Belotti, M., Benitez, J., Berger, A., Borg, A., Bradbury, A.R., Brunet, J., Buys, S.S., Caldes, T., Caligo, M.A., Campbell, I., Caputo, S.M., Chiquette, J., Claes, K.B.M., Collee, J.M., Couch, F.J., Coupier, I., Daly, M.B., Davidson, R., Diez, O., Domchek, S.M., Donaldson, A., Dorfling, C.M., Eeles, R., Feliubadalo, L., Foretova, L., Fowler, J., Friedman, E., Frost, D., Ganz, P.A., Garber, J., Garcia-Barberan, V., Glendon, G., Godwin, A.K., Garcia, E.B.G., Gronwald, J., Hahnen, E., Hamann, U., Henderson, A., Hendricks, C.B., Hopper, J.L., Hulick, P.J., Imyanitov, E.N., Isaacs, C., Izatt, L., Izquierdo, A., Jakubowska, A., Kaczmarek, K., Kang, E., Karlan, B.Y., Kets, C.M., Kim, S.W., Kim, Z., Kwong, A., Laitman, Y., Lasset, C., Lee, M.H., Lee, J.W., Lee, J., Lester, J., Lesueur, F., Loud, J.T., Lubinski, J., Mebirouk, N., Meijers-Heijboer, H.E.J., Meindl, A., Miller, A., Montagna, M., Mooij, T.M., Morrison, P.J., Mouret-Fourme, E., Nathanson, K.L., Neuhausen, S.L., Nevanlinna, H., Niederacher, D., Nielsen, F.C., Nussbaum, R.L., Offit, K., Olah, E., Ong, K.R., Ottini, L., Park, S.K., Peterlongo, P., Pfeiler, G., Phelan, C.M., Poppe, B., Pradhan, N., Radice, P., Ramus, S.J., Rantala, J., Robson, M., Rodriguez, G.C., Schmutzler, R.K., Selkirk, C.G.H., Shah, P.D., Simard, J., Singer, C.F., Sokolowska, J., Stoppa-Lyonnet, D., Sutter, C., Tan, Y.Y., Teixeira, M.R., Teo, S.H., Terry, M.B., Thomassen, M., Tischkowitz, M., Toland, A.E., Tucker, K.M., Tung, N., Asperen, C.J. van, Engelen, K. van, Rensburg, E.J. van, Wang-Gohrke, S., Wappenschmidt, B., Weitzel, J.N., Yannoukakos, D., Greene, M.H., Rookus, M.A., Easton, D.F., Chenevix-Trench, G., Antoniou, A.C., Goldgar, D.E., Olopade, O.I., Rebbeck, T.R., Huo, D.Z., GEMO Study Collaborators, HEBON, EMBRACE |
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| Přispěvatelé: | Clinical Genetics, Damage and Repair in Cancer Development and Cancer Treatment (DARE), Targeted Gynaecologic Oncology (TARGON), Leslie, Goska [0000-0001-5756-6222], Tischkowitz, Marc [0000-0002-7880-0628], Easton, Douglas [0000-0003-2444-3247], Antoniou, Antonis [0000-0001-9223-3116], Apollo - University of Cambridge Repository, Klinische Genetica, MUMC+: DA KG Polikliniek (9), RS: GROW - R4 - Reproductive and Perinatal Medicine, Human Genetics, ARD - Amsterdam Reproduction and Development, Epidemiology and Data Science, Human genetics, CCA - Cancer biology and immunology, Amsterdam Neuroscience - Complex Trait Genetics, Amsterdam Reproduction & Development (AR&D) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Oncology
Cancer Research LOCI Disease DISEASE Body Mass Index breast cancer risk 0302 clinical medicine Risk Factors GENETIC-VARIANTS EPIDEMIOLOGY skin and connective tissue diseases 2. Zero hunger BRCA1 Protein Articles Prognosis INSULIN 3. Good health Women's cancers Radboud Institute for Health Sciences [Radboudumc 17] FAMILY 030220 oncology & carcinogenesis OBESITY BIOLOGICAL PATHWAYS Female Risk assessment Adult medicine.medical_specialty Breast Neoplasms Polymorphism Single Nucleotide EMBRACE GEMO Study Collaborators BMI 03 medical and health sciences Breast cancer SDG 3 - Good Health and Well-being BRCA1/2 Internal medicine Mendelian randomization medicine Journal Article Humans Genetic Predisposition to Disease HEBON BRCA2 Protein IDENTIFICATION Proportional hazards model business.industry Mendelian Randomization Analysis medicine.disease Obesity Confidence interval Body Height Mutation WEIGHT business Body mass index |
| Zdroj: | Qian, F, Wang, S, Mitchell, J, McGuffog, L, Barrowdale, D, Leslie, G, Oosterwijk, J C, Chung, W K, Evans, D G, Engel, C, Kast, K, Aalfs, C M, Adank, M A, Adlard, J, Agnarsson, B A, Aittomäki, K, Alducci, E, Andrulis, I L, Arun, B K, Ausems, M G E M, Azzollini, J, Barouk-Simonet, E, Barwell, J, Belotti, M, Benitez, J, Berger, A, Borg, A, Bradbury, A R, Brunet, J, Buys, S S, Caldes, T, Caligo, M A, Campbell, I, Caputo, S M, Chiquette, J, Claes, K B M, Margriet Collée, J, Couch, F J, Coupier, I, Daly, M B, Davidson, R, Diez, O, Domchek, S M, Donaldson, A, Dorfling, C M, Eeles, R, Feliubadaló, L, Foretova, L, Fowler, J, Friedman, E, Thomassen, M & GEMO Study Collaborators 2019, ' Height and Body Mass Index as Modifiers of Breast Cancer Risk in BRCA1/2 Mutation Carriers : A Mendelian Randomization Study ', National Cancer Institute. Journal , vol. 111, no. 4, pp. 350-364 . https://doi.org/10.1093/jnci/djy132 Journal of the National Cancer Institute, 111(4):djy132, 350-364. Oxford University Press JNCI: Journal of the National Cancer Institute, 111(4), 350-364. OXFORD UNIV PRESS INC JOURNAL OF THE NATIONAL CANCER INSTITUTE, 111(4):132, 350-364. Oxford University Press Journal of the National Cancer Institute, 111(4), 350. Oxford University Press Journal of the National Cancer Institute, 111, 350-364 Qian, F, Wang, S, Mitchell, J, McGuffog, L, Barrowdale, D, Leslie, G, Oosterwijk, J C, Chung, W K, Evans, D G, Engel, C, Kast, K, Aalfs, C M, Adank, M A, Adlard, J, Agnarsson, B A, Aittomäki, K, Alducci, E, Andrulis, I L, Arun, B K, Ausems, M G E M, Azzollini, J, Barouk-Simonet, E, Barwell, J, Belotti, M, Benitez, J, Berger, A, Borg, A, Bradbury, A R, Brunet, J, Buys, S S, Caldes, T, Caligo, M A, Campbell, I, Caputo, S M, Chiquette, J, Claes, K B M, Margriet Collée, J, Couch, F J, Coupier, I, Daly, M B, Davidson, R, Diez, O, Domchek, S M, Donaldson, A, Dorfling, C M, Eeles, R, Feliubadaló, L, Foretova, L, Meijers-Heijboer, H E J, van Engelen, K, HEBON, EMBRACE, GEMO Study Collaborators, Greene, M H, Antoniou, A C, Goldgar, D E, Olopade, O I, Rebbeck, T R & Huo, D 2019, ' Height and Body Mass Index as Modifiers of Breast Cancer Risk in BRCA1/2 Mutation Carriers: A Mendelian Randomization Study ', Journal of the National Cancer Institute, vol. 111, no. 4, pp. 350-364 . https://doi.org/10.1093/jnci/djy132 Journal of the National Cancer Institute, 111(4):132, 350-364. Oxford University Press Qian, F, Wang, S, Mitchell, J, Mcguffog, L, Barrowdale, D, Leslie, G, Oosterwijk, J C, Chung, W K, Evans, D G, Engel, C, Kast, K, Aalfs, C M, Adank, M A, Adlard, J, Agnarsson, B A, Aittomäki, K, Alducci, E, Andrulis, I L, Arun, B K, Ausems, M G E M, Azzollini, J, Barouk-simonet, E, Barwell, J, Belotti, M, Benitez, J, Berger, A, Borg, A, Bradbury, A R, Brunet, J, Buys, S S, Caldes, T, Caligo, M A, Campbell, I, Caputo, S M, Chiquette, J, Claes, K B M, Margriet Collée, J, Couch, F J, Coupier, I, Daly, M B, Davidson, R, Diez, O, Domchek, S M, Donaldson, A, Dorfling, C M, Eeles, R, Feliubadaló, L, Foretova, L, Fowler, J, Friedman, E, Frost, D, Ganz, P A, Garber, J, Garcia-barberan, V, Glendon, G, Godwin, A K, Gómez Garcia, E B, Gronwald, J, Hahnen, E, Hamann, U, Henderson, A, Hendricks, C B, Hopper, J L, Hulick, P J, Imyanitov, E N, Isaacs, C, Izatt, L, Izquierdo, Á, Jakubowska, A, Kaczmarek, K, Kang, E, Karlan, B Y, Kets, C M, Kim, S, Kim, Z, Kwong, A, Laitman, Y, Lasset, C, Hyuk Lee, M, Won Lee, J, Lee, J, Lester, J, Lesueur, F, Loud, J T, Lubinski, J, Mebirouk, N, Meijers-heijboer, H E J, Meindl, A, Miller, A, Montagna, M, Mooij, T M, Morrison, P J, Mouret-fourme, E, Nathanson, K L, Neuhausen, S L, Nevanlinna, H, Niederacher, D, Nielsen, F C, Nussbaum, R L, Offit, K, Olah, E, Ong, K, Ottini, L, Park, S K, Peterlongo, P, Pfeiler, G, Phelan, C M, Poppe, B, Pradhan, N, Radice, P, Ramus, S J, Rantala, J, Robson, M, Rodriguez, G C, Schmutzler, R K, Hutten Selkirk, C G, Shah, P D, Simard, J, Singer, C F, Sokolowska, J, Stoppa-lyonnet, D, Sutter, C, Yen Tan, Y, Teixeira, R M, Teo, S H, Terry, M B, Mads, T, Marc, T, Amanda, E T, Katherine, M T, Nadine, T, Van Asperen, C J, Van Engelen, K, Van Rensburg, E J, Wang-gohrke, S, Wappenschmidt, B, Weitzel, J N, Yannoukakos, D, Greene, M H, Rookus, M A, Easton, D F, Chenevix-trench, G, Antoniou, A C, Goldgar, D E, Olopade, O I, Rebbeck, T R & Huo, D 2019, ' Height and Body Mass Index as Modifiers of Breast Cancer Risk in BRCA1/2 Mutation Carriers: A Mendelian Randomization Study ', Journal of the National Cancer Institute, vol. 111, no. 4, pp. 350-364 . https://doi.org/10.1093/jnci/djy132 Qian, F; Wang, S; Mitchell, J; McGuffog, L; Barrowdale, D; Leslie, G; et al.(2018). Height and Body Mass Index as Modifiers of Breast Cancer Risk in BRCA1/2 Mutation Carriers: A Mendelian Randomization Study.. Journal of the National Cancer Institute. doi: 10.1093/jnci/djy132. UCLA: Retrieved from: http://www.escholarship.org/uc/item/8d25027s Journal of the National Cancer Institute, 111, 4, pp. 350-364 Journal of the National Cancer Institute, 111(4), 350-364. Oxford University Press |
| ISSN: | 0027-8874 |
| Popis: | Contains fulltext : 206539.pdf (Publisher’s version ) (Closed access) BACKGROUND: BRCA1/2 mutations confer high lifetime risk of breast cancer, although other factors may modify this risk. Whether height or body mass index (BMI) modifies breast cancer risk in BRCA1/2 mutation carriers remains unclear. METHODS: We used Mendelian randomization approaches to evaluate the association of height and BMI on breast cancer risk, using data from the Consortium of Investigators of Modifiers of BRCA1/2 with 14 676 BRCA1 and 7912 BRCA2 mutation carriers, including 11 451 cases of breast cancer. We created a height genetic score using 586 height-associated variants and a BMI genetic score using 93 BMI-associated variants. We examined both observed and genetically determined height and BMI with breast cancer risk using weighted Cox models. All statistical tests were two-sided. RESULTS: Observed height was positively associated with breast cancer risk (HR = 1.09 per 10 cm increase, 95% confidence interval [CI] = 1.0 to 1.17; P = 1.17). Height genetic score was positively associated with breast cancer, although this was not statistically significant (per 10 cm increase in genetically predicted height, HR = 1.04, 95% CI = 0.93 to 1.17; P = .47). Observed BMI was inversely associated with breast cancer risk (per 5 kg/m2 increase, HR = 0.94, 95% CI = 0.90 to 0.98; P = .007). BMI genetic score was also inversely associated with breast cancer risk (per 5 kg/m2 increase in genetically predicted BMI, HR = 0.87, 95% CI = 0.76 to 0.98; P = .02). BMI was primarily associated with premenopausal breast cancer. CONCLUSION: Height is associated with overall breast cancer and BMI is associated with premenopausal breast cancer in BRCA1/2 mutation carriers. Incorporating height and BMI, particularly genetic score, into risk assessment may improve cancer management. |
| Databáze: | OpenAIRE |
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