Sulfated neo-clerodane diterpenoids and triterpenoid saponins from Sheareria nana S. Moore
| Autor: | Jing-Yu Liang, Zhengxiang Xia, Zhongyan Tang, Feng Zhang, Junmei Shen |
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| Rok vydání: | 2017 |
| Předmět: |
Stereochemistry
Scutellaria Biology 01 natural sciences Diterpenes Clerodane Triterpenoid Sulfation Cell Line Tumor Drug Discovery Humans Triterpenoid saponin Pharmacology chemistry.chemical_classification Molecular Structure 010405 organic chemistry Sheareria Biological activity General Medicine Saponins biology.organism_classification Antineoplastic Agents Phytogenic 0104 chemical sciences 010404 medicinal & biomolecular chemistry Sheareria nana Phytochemical chemistry |
| Zdroj: | Fitoterapia. 124 |
| ISSN: | 1873-6971 |
| Popis: | Three novel neo-clerodane diterpenoids Sheareria A-C (1-3) together with three known triterpenoid saponins were isolated from the whole herb of Sheareria nana S. Moore. Their structures were established by spectroscopic and chemical method. This is the first natural sulfated neo-clerodane diterpenoids. This is the first report of all these compounds from this plant. These neo-clerodane diterpenoids and triterpenoid saponins from S. nana S. Moore may be considered as chemotaxonomic markers for the genus. The compounds isolated were evaluated for their cytotoxic effects against three cancer cell lines, the test substances demonstrated selectivity toward the cancer cells. To date, this is the first report on the phytochemical and biological activity of secondary metabolites from S. nana S. Moore. |
| Databáze: | OpenAIRE |
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