Oxytocin mediates the inhibitory action of acute lithium on the morphine dependence in rats
| Autor: | Jian Hong Li, Chao You Song, Zhen Dong You, Chang Lin Lu, Cheng He |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
Pain Threshold Hypothalamo-Hypophyseal System Lithium (medication) Narcotic Antagonists Physical dependence Pharmacology Oxytocin Inhibitory postsynaptic potential Drug Administration Schedule Oxytocin Antagonist Rats Sprague-Dawley Antimanic Agents Conditioning Psychological medicine Animals Drug Interactions Pain Measurement Behavior Animal Dose-Response Relationship Drug Morphine Naloxone Neurosecretion Chemistry General Neuroscience General Medicine Psychological dependence Conditioned place preference Rats Substance Withdrawal Syndrome Analgesics Opioid Hypothalamus Anterior medicine.symptom Lithium Chloride Morphine Dependence hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Neuroscience Research. 41:143-150 |
| ISSN: | 0168-0102 |
| DOI: | 10.1016/s0168-0102(01)00272-3 |
| Popis: | The role of central oxytocin in inhibitory action of lithium on the development of morphine dependence was behavioral investigated in rats. Acute lithium could enhance the morphine-induced analgesia in rats with or without chronic morphine treatment; this effect could be inhibited by intraventricular injection of oxytocin antagonist d (CH2)5-Tyr (Me)-[Orn8]-Vasotocin (OVT). Lithium could attenuate naloxone-precipitated withdrawal signs in morphine dependent rats. The reduction of the expression of naloxone-precipitated withdrawal signs by lithium was reversed by ICV of OVT. The lithium significantly inhibited the conditioned place preference (CPP) induced by morphine, which inhibitory action of lithium could also reverse by ICV injection of OVT. These results suggested that lithium might inhibit the physical dependence on morphine as well as psychological dependence in rats, and that this inhibitory effect of lithium on the development of morphine dependence might be associated with oxytocin systems in the central nervous system. |
| Databáze: | OpenAIRE |
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