Future perspectives in cancer immunotherapy
| Autor: | Giuseppe Curigliano, Marinos Tsiatas, Giannis Mountzios |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty business.industry medicine.medical_treatment Cancer Context (language use) General Medicine Immunotherapy medicine.disease Chimeric antigen receptor Oncolytic virus Clinical trial 03 medical and health sciences Prostate cancer 030104 developmental biology 0302 clinical medicine Cancer immunotherapy 030220 oncology & carcinogenesis Internal medicine Immunology Perspective medicine business |
| Zdroj: | Annals of translational medicine. 4(14) |
| ISSN: | 2305-5839 |
| Popis: | The advent of immunotherapy has transformed the treatment paradigm of several solid tumors and is expected to influence the therapeutic algorithm even more in the future following the results of numerous ongoing clinical trials in a wide range of malignancies. Exploiting the anti-cancer effect of the immune system with the use of vaccines, viral vectors, and more lately with immune check-point inhibitors and chimeric antigen receptor modification, has been proven a successful therapeutic strategy in a broad spectrum of tumors. In particular, immune check-point inhibition in melanoma, non-small-cell lung cancer and renal cancer, peptide vaccination in prostate cancer and glioblastoma, and oncolytic immunotherapy in melanoma are well-established therapeutic modalities that have obtained approval by regulatory authorities and are already in clinical use. A large number of ongoing clinical trials involving thousands of patients are currently seeking to define the appropriate tumor type, therapeutic setting, treatment combination and patient populations in order to maximize clinical benefit from immunotherapeutic agents. In this context, identification of the patients whose tumors are most likely to respond to immunotherapy by the use of appropriate biomarkers will be crucial for the optimal implementation of immunotherapy into the therapeutic armamentarium. |
| Databáze: | OpenAIRE |
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