Convergent and rapid assembly of substituted 2-pyridones through formation of N-alkenyl alkynylamides followed by gold-catalyzed cycloisomerization

Autor:	Imase, Hidetomo, Noguchi, Keiichi, Hirano, Masao, Tanaka, Ken
Rok vydání:	2008
Předmět:	Molecular Structure Chemistry Pyridones Organic Chemistry Cationic polymerization pyridone deriv prepn Stereoisomerism Alkenes triphenylphosphine gold chloride silver tetrafluoroborate cationic enyne cycloisomerization catalyst Biochemistry Combinatorial chemistry Amides Catalysis Cycloisomerization Cyclization Alkynes Organic chemistry Imines alkynylamide alkenyl deriv prepn gold catalyst cycloisomerization Physical and Theoretical Chemistry Organogold Compounds alkynoic acid ketone primary amine imine formation acylation
Zdroj:	Organic letters. 10(16)
ISSN:	1523-7052
Popis:	A new method for the convergent and rapid assembly of substituted 2-pyridones was developed through the formation of N-alkenyl alkynylamides (amide-linked 1,5-enynes) by N-acylation of imines with alkynoyl chlorides and the subsequent cationic Au(I)/PPh3-catalyzed cycloisomerization. [on SciFinder(R)]
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d590b375c4250b14f10918d95b4751dd https://pubmed.ncbi.nlm.nih.gov/18636742 Zobrazit plný text záznamu