Diabetes and Bone Fragility
Autor: | Sebastián Antonio Gutiérrez-Romero, Camila Romero-Díaz, Carlos O. Mendivil, Daniela Duarte-Montero |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
medicine.medical_specialty
Anabolism endocrine system diseases Endocrinology Diabetes and Metabolism Osteoporosis Physiology 030209 endocrinology & metabolism Disease Review 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Diabetes mellitus Osteoclast Epidemiology Internal Medicine medicine Bone Bones business.industry nutritional and metabolic diseases medicine.disease Osteopenia Denosumab medicine.anatomical_structure business Fractures medicine.drug |
Zdroj: | Diabetes Therapy |
ISSN: | 1869-6961 1869-6953 |
Popis: | Diabetes is a highly prevalent disease with complications that impact most bodily systems. However, the impact of diabetes on bone health is frequently ignored or underestimated. Both type 1 (T1D) and type 2 diabetes (T2D) are associated with a higher risk of fractures, albeit through different mechanisms. T1D is characterized by near total insulinopenia, which affects the anabolic tone of bone and results in reduced bone mineral density (BMD). Meanwhile, patients with T2D have normal or high BMD, but carry an increased risk of fractures due to alterations of bone microarchitecture and a local humoral environment that stimulates osteoclast activity. Chronic hyperglycemia induces non-enzymatic glycation of collagen in both types of diabetes. Epidemiological evidence confirms a largely increased fracture risk in T1D and T2D, but also that it can be substantially reduced by opportune monitoring of fracture risk and appropriate treatment of both diabetes itself and osteopenia or osteoporosis if they are present. In this review, we summarize the mechanistic, epidemiological, and clinical evidence that links diabetes and bone fragility, and describe the impact of available diabetes treatments on bone health. |
Databáze: | OpenAIRE |
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