Synthesis and Pharmacological Evaluation of 1,2,3,4-Tetrahydro-.BETA.-carboline Derivatives
| Autor: | Minoru Taguchi, Katsuo Hatayama, Yoshimi Tuyuki, Yutaka Kawashima, Akiyo Horiguchi, Hiroaki Araki, Yasuko Karasawa |
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| Rok vydání: | 1995 |
| Předmět: |
Male
β carboline derivatives Magnetic Resonance Spectroscopy Ratón Potassium cyanide Chemical synthesis Lipid peroxidation Mice Structure-Activity Relationship chemistry.chemical_compound Drug Discovery Animals Structure–activity relationship Rats Wistar Hypoxia Potassium Cyanide Brain Diseases Mice Inbred ICR Chemistry General Chemistry General Medicine In vitro Rats Neuroprotective Agents Biochemistry Toxicity Lipid Peroxidation Carbolines |
| Zdroj: | Chemical and Pharmaceutical Bulletin. 43:783-787 |
| ISSN: | 1347-5223 0009-2363 |
| DOI: | 10.1248/cpb.43.783 |
| Popis: | A series of 1, 2, 3, 4-tetrahydro-β-carbolines has been synthesized and evaluated for cerebral protecting effects against lipid peroxidation and potassium cyanide intoxication in mice. Most of the compounds synthesized had potent effects against lipid peroxidation. Among them, 1-(3, 5-dimethoxyphenyl)-2-propyl-1, 2, 3, 4-tetrahydro-β-carboline (22) was found to have a combination of potent effects against both lipid peroxidation and potassium cyanide intoxication. Structure-activity relationships are discussed. |
| Databáze: | OpenAIRE |
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