Excretable Lanthanide Nanoparticle for Biomedical Imaging and Surgical Navigation in the Second Near‐Infrared Window
| Autor: | Qing Zhang, Zhen Cheng, Yifan Wu, Daifeng Li, Aixi Yu, Baisong Chang, Jianqiang Liu, Shuqing He, Zhanhong Xiang, Qiang Liu, Chao Jian, Ying Yuan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
excretable lanthanide nanoparticles
liposomes General Chemical Engineering medicine.medical_treatment Ischemia General Physics and Astronomy Medicine (miscellaneous) Spleen 02 engineering and technology 010402 general chemistry 01 natural sciences Biochemistry Genetics and Molecular Biology (miscellaneous) surgical navigation medicine General Materials Science Embolization lcsh:Science second near‐infrared window Full Paper Chemistry General Engineering Mononuclear phagocyte system Full Papers 021001 nanoscience & nanotechnology medicine.disease 0104 chemical sciences Autofluorescence medicine.anatomical_structure vascular disorders imaging lcsh:Q Lymph 0210 nano-technology Perfusion Preclinical imaging Biomedical engineering |
| Zdroj: | Advanced Science, Vol 6, Iss 23, Pp n/a-n/a (2019) Advanced Science |
| ISSN: | 2198-3844 |
| Popis: | Recently, various second near‐infrared window (NIR‐II, 1000–1700 nm) fluorophores have been synthesized for in vivo imaging with nonradiation, high resolution, and low autofluorescence. However, most of the NIR‐II fluorophores, especially inorganic nanoprobes, are mainly retained in the reticuloendothelial system (RES) such as the liver and spleen, leading to long‐term safety concerns. Herein, a type of lanthanide‐based excretable NIR‐II nanoparticle, RENPs@Lips, which can be quickly cleared out of body after intravenous administration with half‐lives of 23.0 h for the liver and 14.9 h for the spleen, is reported. Interestingly, over 90% of RENPs@Lips can be excreted through a hepatobiliary system within 72 h postinjection. The moderate blood half‐time (T 1/2 = 17.96 min) allows for multifunctional applications in delineating the hemodynamics of vascular disorders (artery thrombosis, ischemia, and tumor angiogenesis) and monitoring blood perfusion in response to acute ischemia. In addition, RENPs@Lips exhibit high performance in identifying orthotopic tumor vessels intraoperatively and embolization surgery under NIR‐II imaging navigation. Moreover, excellent signal‐to‐background ratio (SBR) is successfully achieved to facilitate sentinel lymph nodes biopsy (SLNB) with tumor‐bearing mice. The high biocompatibility, favorable excretability, and outstanding optical properties warrant RENPs@Lips as novel promising NIR‐II nanoparticles for future applications and translation into an interdisciplinary amalgamation of research in diverse fields. Here, a type of liposome‐coated lanthanide second near‐infrared window (NIR‐II) nanoparticle, RENPs@Lips, is reported, demonstrating that over 90% can be excreted through the hepatobiliary system within 72 h postinjection. Further work demonstrates the capability of delineating the hemodynamics of vascular disorders and accomplishing surgery under NIR‐II imaging navigation, showing great potential of excretable RENPs@Lips for future applications and translations in diverse fields. |
| Databáze: | OpenAIRE |
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