Association of heart failure severity with risk of diabetes:a Danish nationwide cohort study
| Autor: | Charlotte Andersson, Allan Vaag, Malene Nøhr Demant, Christian Torp-Pedersen, Gunnar H. Gislason, Lars Køber |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
Risk medicine.medical_specialty Epidemiology Denmark Endocrinology Diabetes and Metabolism Severity of Illness Index Cohort Studies Internal medicine Diabetes mellitus Severity of illness Internal Medicine medicine Humans Prediction and prevention of type 2 diabetes Registries Aged Aged 80 and over Heart Failure Proportional hazards model business.industry Incidence Furosemide Middle Aged Prognosis medicine.disease Diabetes Mellitus Type 2 Heart failure Cohort Cardiac complications Cardiology Female business medicine.drug Cohort study |
| Zdroj: | Demant, M N, Gislason, G H, Køber, L, Vaag, A, Torp-Pedersen, C & Andersson, C 2014, ' Association of heart failure severity with risk of diabetes : a Danish nationwide cohort study ', Diabetologia, vol. 57, no. 8, pp. 1595-1600 . https://doi.org/10.1007/s00125-014-3259-z |
| DOI: | 10.1007/s00125-014-3259-z |
| Popis: | Aims/hypothesis: Heart failure has been suggested to increase the risk of developing diabetes. We investigated the relation between heart failure severity, defined by loop-diuretic dosage, and the risk of developing diabetes in a nationwide cohort of patients with heart failure. Methods: We followed all Danish patients discharged from hospitalisation for first-time heart failure in 1997-2010, without prior use of hypoglycaemic agents, until a claimed prescription for hypoglycaemic agents, death or 31 December 2010. The association of loop-diuretic dosage (furosemide equivalents) 90 days after discharge (study baseline) with risk of diabetes was estimated by multivariate Cox regression models. Results: In total, 99,362 patients were included and divided into five loop-diuretic dose groups: 30,838 (31%) used no loop diuretics; 24,389 (25%) used >0-40 mg/day; 17,355 (17%) used >40-80 mg/day; 11,973 (12%) used >80-159 mg/day; and 14,807 (15%) used ≥160 mg/day. A total of 7,958 patients (8%) developed diabetes. Loop-diuretic dosages were associated with an increased risk of developing diabetes in a dose-dependent manner. Concomitant use of renin-angiotensin system inhibitors (RASis) attenuated the risk (p value for interaction |
| Databáze: | OpenAIRE |
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