Lipid Digestion in Cystic Fibrosis: Comparison of Conventional and High-Lipase Enzyme Therapy Using the Mixed-Triglyceride Breath Test
| Autor: | Ephrem Eggermont, K. De Boeck, I. Delbeke, G. Veereman-Wauters, Yvo Ghoos |
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| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.medical_specialty Pancreatic disease Adolescent Cystic Fibrosis Cystic fibrosis chemistry.chemical_compound Internal medicine Humans Medicine Lipase Child Triglycerides Breath test Carbon Isotopes Triglyceride Gastric emptying medicine.diagnostic_test biology business.industry Gastroenterology medicine.disease Dietary Fats Endocrinology Breath Tests Gastric Emptying chemistry Pediatrics Perinatology and Child Health biology.protein Digestion Female Caprylates business Lipid digestion |
| Zdroj: | Journal of Pediatric Gastroenterology & Nutrition. 26:408-411 |
| ISSN: | 0277-2116 |
| Popis: | Background: Fat maldigestion occurs in most patients with cystic fibrosis. Conventional pancreatic enzyme replacement therapy partially corrects this defect. In this study, the mixed-triglyceride breath test was used to evaluate whether high-lipase enzymes are equivalent to conventional enzymes in improving fat maldigestion in children with cystic fibrosis. Methods: Fat digestion was studied in 11 patients with a mean age of 10.5 years. The mean intake of conventional enzyme capsules a day was 19. Four 13 C mixed-triglyceride tests were performed on separate days and in random order. One test was taken without enzyme substitution, one with three capsules of 8,000 FIP units Creon (pancreatinum. Kali-chemie Pharma, Hannover, Germany) and one with one capsule of 25.000 FIP units. The fourth test was made with 13 C octanoic acid to study gastric emptying time. Results: Without enzyme intake, the mean cumulative percentage of 13 C dose exhaled after 6 hours was 7.2 ± 3.7%. This increased to 14.4 ± 4% with intake of conventional pancreatinum and to 14.3 ± 5.1% with intake of high-lipase pancreatinum (p = 0.0008 for both; paired t-test). There was no difference between both treatments. Also, the time course of 13 C exhalation measured by percentage of 13 CO 2 exhaled per hour did not differ between enzyme treatments. Conclusions: The 13 C mixed-triglyceride test is noninvasive and documents improved lipid digestion with pancreatic enzyme replacement therapy. If the lipase dose is kept constant, results obtained with high-lipase preparations are equivalent to those obtained with conventional preparations. |
| Databáze: | OpenAIRE |
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