Retinoids regulate a developmental checkpoint for tissue regeneration in Drosophila
| Autor: | Michelle Cheng, Adrian Halme, Iswar K. Hariharan |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.drug_class media_common.quotation_subject DEVBIO Biology General Biochemistry Genetics and Molecular Biology Article chemistry.chemical_compound Retinoids Transcription (biology) medicine Animals Wings Animal Retinoid Metamorphosis media_common Body Patterning Wound Healing Agricultural and Biological Sciences(all) Biochemistry Genetics and Molecular Biology(all) Regeneration (biology) fungi Pupa Anatomy Cell biology Transplantation Genes cdc Imaginal disc chemistry Larva Drosophila Female General Agricultural and Biological Sciences Ecdysone Genetic screen |
| Zdroj: | Current biology : CB. 20(5) |
| ISSN: | 1879-0445 |
| Popis: | Drosophila melanogaster larvae have a remarkable capacity for regenerative growth: Damage to their imaginal discs, the larval precursors of adult structures, elicits a robust proliferative response from the surviving tissue [1–4]. However, as in other organisms, developmental progression and differentiation can restrict regenerative capacity of Drosophila tissues. Experiments in Drosophila and other holometabolous insects have demonstrated that either damage to imaginal tissues [5, 6] or transplantation of a damaged imaginal disc [7, 8] delays the onset of metamorphosis, a time when the imaginal discs undergo morphogenesis and differentiation into their adult structures. Therefore, in Drosophila there appears to be a mechanism that senses tissue damage and extends the larval phase to coordinate tissue regeneration with the overall developmental program of the organism. However, how such a pathway functions remains unknown. Here we demonstrate that a developmental checkpoint extends larval growth after imaginal disc damage by inhibiting the transcription of the gene encoding PTTH, a neuropeptide that promotes the release of the steroid hormone ecdysone. Using a genetic screen, we identify a previously unsuspected role for retinoid biosynthesis in regulating PTTH expression and delaying development in response to tissue damage. Retinoid signaling plays an important, but poorly defined role in several vertebrate regeneration models [9–11]. Our findings demonstrate that retinoid biosynthesis in Drosophila is important for the maintenance of a permissive condition for regenerative growth. |
| Databáze: | OpenAIRE |
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