Electrocatalytical oxidation and sensitive determination of acetaminophen on glassy carbon electrode modified with graphene-chitosan composite
| Autor: | Lizhang Huang, Meixia Zheng, Xili Cai, Fei Gao, Shulian Jiang, Feng Gao, Qingxiang Wang |
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| Rok vydání: | 2012 |
| Předmět: |
Materials science
Time Factors Analytical chemistry Bioengineering Electrons Electrochemistry Redox Catalysis Nanocomposites Biomaterials Diffusion Adsorption Electrodes Acetaminophen Detection limit Chitosan Nanocomposite Electrochemical Techniques Hydrogen-Ion Concentration Carbon Solutions Kinetics Mechanics of Materials Electrochemical reaction mechanism Graphite Differential pulse voltammetry Glass Cyclic voltammetry Oxidation-Reduction Nuclear chemistry |
| Zdroj: | Materials scienceengineering. C, Materials for biological applications. 33(3) |
| ISSN: | 1873-0191 |
| Popis: | The electrochemical behaviors of acetaminophen (ACOP) on a graphene-chitosan (GR-CS) nanocomposite modified glassy carbon electrode (GCE) were investigated by cyclic voltammetry (CV), chronocoulometry (CC) and differential pulse voltammetry (DPV). Electrochemical characterization showed that the GR-CS nanocomposite had excellent electrocatalytic activity and surface area effect. As compared with bare GCE, the redox signal of ACOP on GR-CS/GCE was greatly enhanced. The values of electron transfer rate constant (ks), diffusion coefficient (D) and the surface adsorption amount (Γ(*)) of ACOP on GR-CS/GCE were determined to be 0.25s(-1), 3.61×10(-5) cm(2) s(-1) and 1.09×10(-9) mol cm(-2), respectively. Additionally, a 2e(-)/2H(+) electrochemical reaction mechanism of ACOP was deduced based on the acidity experiment. Under the optimized conditions, the ACOP could be quantified in the range from 1.0×10(-6) to 1.0×10(-4) M with a low detection limit of 3.0×10(-7) M based on 3S/N. The interference and recovery experiments further showed that the proposed method is acceptable for the determination of ACOP in real pharmaceutical preparations. |
| Databáze: | OpenAIRE |
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