Interplay between Klebsiella pneumoniae producing KPC-31 and KPC-3 under treatment with high dosage meropenem: a case report
Autor: | Gabriele Arcari, Alessandra Oliva, Federica Sacco, Federica Maria Di Lella, Giammarco Raponi, Dario Tomolillo, Ambrogio Curtolo, Mario Venditti, Alessandra Carattoli |
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Jazyk: | angličtina |
Rok vydání: | 2022 |
Předmět: |
Microbiology (medical)
Ceftazidime-avibactam Brief Report COVID-19 General Medicine Meropenem Microbial Sensitivity Tests biochemical phenomena metabolism and nutrition bacterial infections and mycoses Ceftazidime beta-Lactamases Anti-Bacterial Agents Klebsiella Infections Drug Combinations Klebsiella pneumoniae KPC Infectious Diseases Bacterial Proteins polycyclic compounds Humans ceftazidime-avibactam klebsiella pneumoniae kpc |
Zdroj: | European Journal of Clinical Microbiology & Infectious Diseases |
ISSN: | 1435-4373 0934-9723 |
Popis: | The objective was to study ceftazidime-avibactam resistant and susceptible Klebsiella pneumoniae isolated from a patient admitted to the Policlinico Umberto I of Rome for SARS-CoV2. Data on the evolution of patient’s conditions, antimicrobial therapies, and microbiological data were collected. Whole-genome sequencing performed by Illumina and Nanopore sequencing methods were used to type the strains. During the hospitalization, a SARS-CoV2-infected patient was colonized by a KPC-producing K. pneumoniae strain and empirically treated with ceftazidime-avibactam (CZA) when presenting spiking fever symptoms. Successively, ST2502 CZA-resistant strain producing the KPC-31 variant gave a pulmonary infection to the patient. The infection was treated with high doses of meropenem. The KPC-31-producing strain disappeared but the patient remained colonized by a KPC-3-producing K. pneumoniae strain. An interplay between highly conserved KPC-31- and KPC-3-producing ST2502 strains occurred in the SARS-CoV2 patient during the hospitalization, selected by CZA and carbapenem treatments, respectively. Supplementary Information The online version contains supplementary material available at 10.1007/s10096-021-04388-y. |
Databáze: | OpenAIRE |
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