Recurrent Infection with Herpes Simplex Virus after Marrow Transplantation: Role of the Specific Immune Response and Acyclovir Treatment
Autor: | James C. Wade, Lila M. Day, Joel D. Meyers, John Crowley |
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Rok vydání: | 1984 |
Předmět: |
Adult
Male Recurrent infections Time Factors Adolescent viruses Lymphocyte Acyclovir HSL and HSV Lymphocyte Activation medicine.disease_cause Recurrence medicine Humans Simplexvirus Immunology and Allergy Child Bone Marrow Transplantation Herpes Genitalis Marrow transplantation business.industry Herpes Simplex Acquired immune system Stomatitis Herpetic Infectious Diseases medicine.anatomical_structure Positive response Herpes simplex virus Bone transplantation Immunology Female business |
Zdroj: | Journal of Infectious Diseases. 149:750-756 |
ISSN: | 1537-6613 0022-1899 |
DOI: | 10.1093/infdis/149.5.750 |
Popis: | Herpes simplex virus (HSV) reactivation is common after marrow transplantation, with some patients developing frequent and severe recurrences. Sixty patients were studied to determine both the effect of the specific lymphocyte response to HSV on subsequent recurrences and the effect of acyclovir treatment on restoration of this response. Patients with a positive response after the first HSV recurrence had fewer second recurrences (13 of 28 vs. 18 of 19; P less than .01) and at a longer interval when they did recur (42 vs. 27 days; P less than .0001). Conversely, patients treated with acyclovir had more frequent second recurrences than did those not treated (18 of 21 vs. 13 of 26; P less than .05) and they were at a shorter interval when they did recur (27 vs. 36 days; P = .001). Treated patients also had lower specific lymphocyte responses to HSV. These data confirm the importance of the specific immune response to HSV in the determination of the course of HSV infection after marrow transplant. |
Databáze: | OpenAIRE |
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