Cardiovascular mechanisms and consequences of obstructive sleep apnoea
| Autor: | P. Van de Heyning, Olivier M. Vanderveken, Johan Verbraecken, Evert Hamans, W. De Backer, Hilde Heuten, Bharati Shivalkar, H. Vrints |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Oral appliance medicine.medical_treatment Population Sudden cardiac death Coronary artery disease Risk Factors Internal medicine medicine Humans Continuous positive airway pressure Myocardial infarction Risk factor education Stroke Sleep Apnea Obstructive education.field_of_study Continuous Positive Airway Pressure business.industry General Medicine medicine.disease nervous system diseases respiratory tract diseases Cardiovascular Diseases Cardiology Human medicine business |
| Zdroj: | Acta clinica Belgica |
| ISSN: | 0001-5512 |
| Popis: | Obstructive sleep apnoea (OSA) is considered as a risk factor for the development of arterial hypertension, coronary artery disease (CAD), myocardial infarction and stroke. These clinical manifestations are the consequences of elevated sympathetic activity, cardiovascular variability, intrathoracic pressure changes, inflammation, oxidative stress, endothelial dysfunction, insulin resistance and thrombosis provoked by OSA. As a result, OSA is often present in patients with cardiovascular disease (CVD) and the increased prevalence of CVD in OSA population raises both cardiovascular morbidity and mortality and the demand of healthcare resources. Observational cohort studies indicate that untreated patients with OSA have an increased risk of fatal and non-fatal cardiovascular events, an increased risk of sudden cardiac death during the sleeping hours and a higher risk of stroke or death from any cause. Continuous positive airway pressure (CPAP) and oral appliance therapy are the two treatments for OSA whose effects on cardiovascular endpoints have been assessed in randomised trials. There is increasing evidence that adequate CPAP therapy leads to a significant reduction in cardiovascular morbidity. |
| Databáze: | OpenAIRE |
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