Preliminary clinical evaluation of glybenclamide in treatment of diabetes mellitus
| Autor: | F W Wolff, W J Rzeszotarski, B F Johnson, C K Bhatia |
|---|---|
| Rok vydání: | 1970 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Chlorpropamide medicine.drug_class Endocrinology Diabetes and Metabolism Blood sugar Blood Sedimentation Pharmacology Transaminase Blood Urea Nitrogen Internal medicine Diabetes mellitus Internal Medicine medicine Diabetes Mellitus Humans Hypoglycemic Agents Insulin Receptor Hypoglycemic reactions Transaminases Triglycerides Clinical Trials as Topic business.industry Bilirubin medicine.disease Alkaline Phosphatase Sulfonylurea Hypoglycemia Blood Cell Count Clinical trial Endocrinology Creatinine Prothrombin Time Female business Clinical evaluation |
| Zdroj: | Diabetes. 19(8) |
| ISSN: | 0012-1797 |
| Popis: | An initial clinical trial with a new hypoglycemic sulfonylurea is described. In most patients, significant reductions in blood sugar and elevations of plasma insulin levels were produced throughout the day, by doses ranging from 2.5 to 15 mg. twice daily. The greatly enhanced activity compared to other sulfonylureas may be due to increased hydrophobic bonding to the receptor vicinity. Two patients developed hypoglycemic reactions. Transient elevations in transaminase levels were the only other toxic effect noted. Our results to date do not suggest that this compound is clinically advantageous to other orally active hypoglycemic agents. |
| Databáze: | OpenAIRE |
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