INFECTION AND COLONISATION OF NEONATES BY HANSENULA ANOMALA
| Autor: | C. A. Hart, R. Whitaker, N. Murphy, C.R. Buchanan, V. Damjanovic, R.W.I. Cooke |
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| Rok vydání: | 1986 |
| Předmět: |
Pediatrics
medicine.medical_specialty Neonatal intensive care unit Flucytosine Gestational Age Infant Premature Diseases Hansenula anomala Pichia Disease Outbreaks Microbiology Amphotericin B Intensive care medicine Humans Anomala Pathogen biology Infant Newborn Rectum General Medicine biology.organism_classification Colonisation England Mycoses Recien nacido Saccharomycetales Drug Therapy Combination |
| Zdroj: | The Lancet. 327:291-293 |
| ISSN: | 0140-6736 |
| DOI: | 10.1016/s0140-6736(86)90827-5 |
| Popis: | Over a 13-month period 52 neonates (10% of those admitted to the Mersey Regional Neonatal Intensive Care Unit) were found to be colonised with the ascosporagenous yeast Hansenula anomala. 8 babies became infected, all but 1 of whom were heavily colonised before infection. 7 of the 8 infected babies were of very low birth-weight (less than 1500 g). All 8 had multiple problems associated with low birth-weight and prematurity and were kept in the intensive care unit. 5 babies had fungaemia, 2 had fungaemia and ventriculitis, and 1 had ventriculitis only. In each case H anomala was the sole pathogen isolated. Anti-Hansenula antibodies developed in 5 babies within 3 months of infection. Infected babies were successfully treated with a combination of 5-flucytosine and amphotericin B. Despite extensive searches the babies appeared to be the only reservoir of the yeast. |
| Databáze: | OpenAIRE |
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