Mapping the extent of disease by multislice computed tomography, magnetic resonance imaging and sentinel node evaluation in stage I and II cervical carcinoma
| Autor: | Shalini Rajaram, S K Bhargava, Sumita Mehta, H Sharma, R P Tripathi, Neerja Goel |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Uterine Cervical Neoplasms Sensitivity and Specificity lcsh:RC254-282 Positive predicative value medicine Humans Radiology Nuclear Medicine and imaging Multislice Cervix Neoplasm Staging Cervical cancer medicine.diagnostic_test business.industry Sentinel Lymph Node Biopsy Reproducibility of Results Magnetic resonance imaging General Medicine FIGO staging Sentinel node medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Magnetic Resonance Imaging Spiral computed tomography Carcinoma cervix medicine.anatomical_structure Oncology sentinel node Female Radiology Tomography business Tomography X-Ray Computed CT MRI |
| Zdroj: | Journal of Cancer Research and Therapeutics, Vol 6, Iss 3, Pp 267-271 (2010) |
| ISSN: | 1998-4138 0973-1482 |
| Popis: | Aims: (1) To map the extent of disease in women with stage I and II carcinoma cervix by multislice spiral computed tomography (CT), magnetic resonance imaging (MRI) and sentinel nodes. (2) To assess accuracy of each modality individually and in conjunction with FIGO clinical staging. Design and Setting: Prospective, single-blind study. Departments of Obstetrics and Gynaecology, Radiodiagnosis, and Pathology, UCMS and GTBH and Division of Radiological Imaging and Bioinformatics, INMAS, Delhi. Material and Method: The study was conducted on 25 women with cervical cancer FIGO stage I and II. Each woman underwent clinical staging, multislice spiral CT and MRI which was compared to the gold-standard histopathology/cytology. The overall accuracy of each modality and improvement of clinical staging by CT/MRI were noted. Sentinel nodes were evaluated by intracervical Patent Blue V dye injection. Statistical Analysis: Sensitivity, specificity, positive and negative predictive values were calculated by 2Χ2 contingency tables. Results: The accuracy of staging by FIGO, CT and MRI was 68%, 52% and 80%, respectively. MRI and CT improved the overall accuracy of FIGO staging to 96% and 80%, respectively. Sentinel nodes were identified in 89% of patients with 91% accuracy. Conclusion: MRI emerges as the most valuable stand-alone modality improving accuracy of FIGO staging to 96%. Sentinel lymph-node evaluation appears promising in evaluating spread beyond cervix. |
| Databáze: | OpenAIRE |
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