In Vitro Fertilization Using Luteinizing Hormone-Releasing Hormone Injections Resulted in Healthy Triplets without Increased Attack Rates in a Hereditary Angioedema Case
| Autor: | Aytül Sin, Ceyda Tunakan Dalgiç, Gökten Bulut, Fatma Düşünür Günsen, Emine Nihal Mete Gökmen |
|---|---|
| Přispěvatelé: | Ege Üniversitesi |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
Pediatrics medicine.medical_specialty medicine.medical_treatment Immunology Case Report 03 medical and health sciences 0302 clinical medicine medicine Triplet Pregnancy Immunology and Allergy Pregnancy Trimesters Danazol Pregnancy 030219 obstetrics & reproductive medicine In vitro fertilisation Angioedema business.industry medicine.disease 030228 respiratory system Hereditary angioedema medicine.symptom business Luteinizing hormone lcsh:RC581-607 medicine.drug |
| Zdroj: | Case Reports in Immunology Case Reports in Immunology, Vol 2018 (2018) |
| ISSN: | 0004-2617 2966-6724 |
| Popis: | WOS: 000426177100001 PubMed ID: 29666724 Hereditary angioedema due to C1-inhibitor deficiency (C1-INH-HAE) is a rare, autosomal dominant disorder. The management of pregnant patients with C1-INH-HAE is a challenge for the physician. Intravenous plasma-derived nanofiltered C1-INH (pdC1INH) is the only recommended option throughout pregnancy, postpartum, and breast feeding period. In order to increase pregnancy rates, physicians use fertilization therapies increasing endogen levels of estrogens. Therefore, these techniques can provoke an increase in the number and severity of edema attacks in C1-INH-HAE. Our patient is a 32-year-old female, diagnosed with C1-INH-HAE type 1 since 2004. She had been taking danazol 50-200 mg/day for 9 years. Due to her pregnancy plans in 2013, danazol was discontinued. PdC1INH was prescribed regularly for prophylactic purpose. Triplet pregnancy occurred by in vitro fertilization using luteinizing hormone-releasing hormone (LHRH) injections. In our patient, LHRH injections were done four times without causing any severe attack during in vitro fertilization. Angioedema did not worsen during pregnancy and delivery due to the prophylactic use of intravenous pdC1INH in our patient. According to the attack frequency and severity, there was no difference between the three pregnancy trimesters. To our knowledge, this is the first published case of C1-INH-HAE receiving in vitro fertilization therapies without any angioedema attacks during pregnancy and delivery and eventually having healthy triplets with the prophylactic use of intravenous pdC1INH. |
| Databáze: | OpenAIRE |
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