Identification and validation of leucine-rich α-2-glycoprotein 1 as a noninvasive biomarker for improved precision in prostate cancer risk stratification

Autor: Rune Kvåle, Anne George, Håkon Ramberg, Vincent J. Gnanapragasam, Fredrik Wiklund, David E. Neal, Ian G. Mills, Wolfgang Lilleby, Ingrid Jenny Guldvik, Helene Hartvedt Grytli, Verena Zuber, Kristin Austlid Taskén, Fahri Saatcioglu, Manuela Zucknick, Bernd Thiede, Peder Rustøen Braadland, Randi Elin Gislefoss, Henrik Grönberg
Přispěvatelé: Gnanapragasam, Vincent [0000-0003-4722-4207], Apollo - University of Cambridge Repository
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: European Urology Open Science
Guldvik, I J, Zuber, V, Braadland, P R, Grytli, H H, Ramberg, H, Lilleby, W, Thiede, B, Zucknick, M, Saatcioglu, F, Gislefoss, R, Kvåle, R, George, A, Grönberg, H, Wiklund, F, Neal, D E, Gnanapragasam, V J, Taskén, K A & Mills, I G 2020, ' Identification and Validation of Leucine-rich α-2-glycoprotein 1 as a Noninvasive Biomarker for Improved Precision in Prostate Cancer Risk Stratification ', European Urology Open Science, vol. 21, pp. 51-60 . https://doi.org/10.1016/j.euros.2020.08.007
European Urology Open Science, Vol 21, Iss, Pp 51-60 (2020)
ISSN: 2666-1683
Popis: Background More accurate risk assessments are needed to improve prostate cancer management. Objective To identify blood-based protein biomarkers that provided prognostic information for risk stratification. Design, setting, and participants Mass spectrometry was used to identify biomarker candidates from blood, and validation studies were performed in four independent cohorts retrospectively collected between 1988 and 2015. Outcome measurements and statistical analysis The primary outcome objectives were progression-free survival, prostate cancer–specific survival (PCSS), and overall survival. Statistical analyses to assess survival and model performance were performed. Results and limitation Serum leucine-rich α-2-glycoprotein 1 (LRG1) was found to be elevated in fatal prostate cancer. LRG1 provided prognostic information independent of metastasis and increased the accuracy in predicting PCSS, particularly in the first 3 yr. A high LRG1 level is associated with an average of two-fold higher risk of disease-progression and mortality in both high-risk and metastatic patients. However, our study design, with a retrospective analysis of samples spanning several decades back, limits the assessment of the clinical utility of LRG1 in today’s clinical practice. Thus, independent prospective studies are needed to establish LRG1 as a clinically useful biomarker for patient management. Conclusions High blood levels of LRG1 are unfavourable in newly diagnosed high-risk and metastatic prostate cancer, and LRG1 increased the accuracy of risk stratification of prostate cancer patients. Patient summary High blood levels of leucine-rich α-2-glycoprotein 1 are unfavourable in newly diagnosed high-risk and metastatic prostate cancer.
Take Home Message High blood levels of leucine-rich α-2-glycoprotein 1 (LRG1) is unfavourable in patients with newly diagnosed high-risk or metastatic prostate cancer. Implementation of a blood test for LRG1 alongside standard risk stratification schemes could provide higher precision in treatment decisions.
Databáze: OpenAIRE
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