Comparison of visual prognoses between natural course of simple hemorrhage and choroidal neovascularization treated with intravitreal bevacizumab in highly myopic eyes: a 1-year follow-up

Autor: Fumi Gomi, Kaori Sayanagi, Kohji Nishida, Yukari Jo, So Goto, Yasushi Ikuno
Rok vydání: 2014
Předmět:
Adult
Indocyanine Green
Male
Vascular Endothelial Growth Factor A
medicine.medical_specialty
genetic structures
Bevacizumab
Adolescent
Visual Acuity
1 year follow up
Angiogenesis Inhibitors
Antibodies
Monoclonal
Humanized
chemistry.chemical_compound
Ophthalmology
medicine
Humans
Intravitreal bevacizumab
Fluorescein Angiography
Coloring Agents
Retrospective Studies
Natural course
medicine.diagnostic_test
business.industry
Retinal Hemorrhage
Retrospective cohort study
General Medicine
Middle Aged
Fluorescein angiography
Prognosis
Refractive Errors
eye diseases
Choroidal Neovascularization
Axial Length
Eye
Choroidal neovascularization
chemistry
Intravitreal Injections
Myopia
Degenerative
Female
sense organs
medicine.symptom
business
Indocyanine green
Tomography
Optical Coherence
medicine.drug
Follow-Up Studies
Zdroj: Retina (Philadelphia, Pa.). 35(3)
ISSN: 1539-2864
Popis: To compare the long-term outcomes of simple hemorrhage (SH) without any treatments and myopic choroidal neovascularization (mCNV) treated with intravitreal bevacizumab in highly myopic eyes.Twenty eyes (17 patients) with SH and 28 eyes (27 patients) with mCNV were included. We retrospectively evaluated the refractive error, axial length, age, best-corrected visual acuity, and the integrity of photoreceptor inner segment/outer segment junction and compared the two groups.The mean patient age was 41.6 ± 11.2 years, the mean refractive error -12.7 ± 3.57 diopters, and the mean axial length was 29.64 ± 1.42 mm. Patients in the SH group were significantly (P0.001) younger than those in the mCNV group (34.8 vs. 46.5 years, respectively). There were no significant differences in other parameters between the groups. Compared with baseline, the best-corrected visual acuity improved significantly (P0.01) at 12 months in both groups. The change in vision at 12 months in the SH group was significantly (P0.05) better than that in the mCNV group, although there were no significant differences at 3 months or 6 months. The final integrity of photoreceptor inner segment/outer segment junction was significantly associated with the final best-corrected visual acuity (P0.05).Eyes with SH had a more favorable visual prognosis compared with eyes with mCNV treated with intravitreal bevacizumab. The differential diagnosis of these pathologies is important.
Databáze: OpenAIRE
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