On Negative Heritability and Negative Estimates of Heritability
Autor: | Kenneth W. Wachter, David Steinsaltz, Andrew Dahl |
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Rok vydání: | 2020 |
Předmět: |
Mixed model
Multifactorial Inheritance Linear mixed model Maximum likelihood Investigations Biology GREML Heritability Quantitative Trait 03 medical and health sciences Quantitative Trait Heritable 0302 clinical medicine Genetic Models Random noise Statistics Genetics Humans Heritable Mathematics 030304 developmental biology 0303 health sciences Models Statistical Models Genetic Genetic Variation Statistical model Statistical Phenotype Model misspecification Epistasis 030217 neurology & neurosurgery Developmental Biology |
Zdroj: | Genetics, vol 215, iss 2 Genetics |
ISSN: | 1943-2631 |
Popis: | We consider the problem of interpreting negative maximum likelihood estimates of heritability that sometimes arise from popular statistical models of additive genetic variation. These may result from random noise acting on estimates of genuinely positive heritability, but we argue that they may also arise from misspecification of the standard additive mechanism that is supposed to justify the statistical procedure. Researchers should be open to the possibility that negative heritability estimates could reflect a real physical feature of the biological process from which the data were sampled. |
Databáze: | OpenAIRE |
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