Chia seed ( Salvia hispanica L .) effects and their molecular mechanisms on unbalanced diet experimental studies: A systematic review

Autor: Mariana Grancieri, Luiza de Paula Dias Moreira, Susanne U. Mertens-Talcott, Hércia Stampini Duarte Martino, Carla de Oliveira Barbosa Rosa, Bárbara Nery Enes, Haira G. Lúcio, Vinícius P. Venâncio, Bárbara Pereira da Silva
Rok vydání: 2020
Předmět:
Zdroj: Journal of Food Science. 85:226-239
ISSN: 1750-3841
0022-1147
Popis: The aim of this review was to compile evidence and understand chia seed effects on unbalanced diet animal studies and the molecular mechanisms on metabolic biomarker modulation. A systematic review was conducted in electronic databases, following PRISMA recommendations. Risk of bias and quality was assessed using SYRCLE toll and ARRIVE guidelines. Seventeen articles were included. Throughout the studies, chia's main effects are associated with AMPK modulation: improvement of glucose and insulin tolerance, lipogenesis, antioxidant activity, and inflammation. Details about randomization and allocation concealment were insufficient, as well as information about blind protocols. Sample size, chia dose, and number of animals evaluated for each parameter were found to be lacking information among the studies. Based on experimental study data, chia has bioactive potential, and its daily consumption may reduce the risk of chronic disease development, mainly due to the antioxidant, anti-inflammatory, hypoglycemic, and hypolipidemic effects of the seed. PRACTICAL APPLICATION: The consumption of chia seeds may improve lipid profile, insulin and glucose tolerance, and reduce risk of cardiovascular disease. Whole seed or its oil presents positive effect, but the effects of chia oil can act faster than the seed.
Databáze: OpenAIRE
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