C‐reactive protein inhibits C3a/C3aR‐dependent podocyte autophagy in favor of diabetic kidney disease

Autor:	Lin Zhang, Wei Li, Minjie Gong, Zeyu Zhang, Xiaodong Xue, Jiarong Mao, Haibao Zhang, Siqi Li, Xiawan Liu, Feng Wu, Jingming Shi, Rongguo Fu
Rok vydání:	2022
Předmět:	Male Podocytes Biochemistry Rats Receptors Complement C-Reactive Protein Autophagy Complement C3a Diabetes Mellitus Genetics Animals Humans Diabetic Nephropathies Female Carrier Proteins Molecular Biology Biotechnology
Zdroj:	The FASEB Journal. 36
ISSN:	1530-6860 0892-6638
DOI:	10.1096/fj.202200198r
Popis:	Numerous studies have reported the pathogenic roles of C-reactive protein (CRP) and complement activation in diabetic kidney disease (DKD) individually. However, considering the potent regulatory effect of CRP on complement activation, it remains unclear whether CRP participates in DKD pathogenesis by regulating complement activation. Moreover, this work focuses on complement activation in rats, which aims at settling the dispute that whether rat CRP can activate the complement system. To address this question, the complement effectors C3a, C5a, and C5b-9 were examined in human patients with diabetic nephropathy (DN) and wt, Crp
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d56cfc1baa609c9dfa5318fe9cab8f2b https://doi.org/10.1096/fj.202200198r Zobrazit plný text záznamu Plný text