SMART syndrome: Classic transient symptoms leading to an unusual unfavorable outcome
| Autor: | Flavie Bompaire, Jean Yves Delattre, L. Zinchenko, C. Gaultier, Annick Monjour, M. Lahutte, Karima Mokhtari, Dimitri Psimaras, Damien Ricard |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Pediatrics Aura Migraine Disorders medicine.medical_treatment Disease 03 medical and health sciences Fatal Outcome 0302 clinical medicine Glioma medicine Humans 030212 general & internal medicine Radiation Injuries Stroke Brain Neoplasms business.industry Headache Middle Aged medicine.disease humanities Surgery Radiation therapy Neurology Migraine Female Neurology (clinical) Headaches medicine.symptom business Complication 030217 neurology & neurosurgery Paraneoplastic Syndromes Nervous System |
| Zdroj: | Revue Neurologique. 173:67-73 |
| ISSN: | 0035-3787 |
| Popis: | Background Stroke-like migraine attacks after radiation therapy (SMART) syndrome is a rare complication of cerebral radiation therapy that usually presents > 10 years after treatment as reversible paroxysmal episodes of neurological dysfunction associated with headaches. Cases We report here on two cases of SMART syndrome in long-term survivors of high-grade glioma for whom neuropathological data were available. The course of the disease was unfavorable. Although the clinico-radiological picture of SMART syndrome clearly differs from classic cerebral radionecrosis, the gross neuropathological lesions observed in our two patients appeared to be similar to those described in focal radionecrosis. Conclusion SMART syndrome may progress from a benign reversible form to a severe and eventually irreversible form. This severe course may also be confused with tumor progression, and lead to permanent disability and inadequate antitumor treatment. Clinicians should be aware of this latter atypical presentation. |
| Databáze: | OpenAIRE |
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