Characteristics of Turkish children with Type 2 diabetes at onset: a multicentre, cross‐sectional study

Autor: Buyuk, Muammer, Aycan, Z., Nalbantoglu, O., Kara, C., ABALI, Saygın, Doger, ESRA, Hatun, S., Mutlu, G. Yesiltepe, Cinaz, P., DEMİRCİOĞLU, SERAP, Ekberzade, A., HATİPOĞLU, NİHAL, Bereket, A., Erbas, M. Y., Akcay, T., Onal, H., Bolu, S., Arslanoglu, I., Yilmaz, A. A., Ucakturk, A., Karabulut, G. S., Tuhan, H. U., Demir, K., Erdeve, S. S., Cayir, Atilla, Siklar, Zeynep, Ergur, Ayca Torel, Ozcabi, Bahar, Haliloglu, Belma, Ozkan, Behzat, Eklioglu, Beray Selver, Kirel, Birgul, Bezen, Digdem, Vuralli, Dogus, Unal, Edip, Sagsak, Elif, Bugrul, Fuat, Catli, Gonul, Korkmaz, Huseyin Anil, Ozbek, Mehmet Nuri, Tayfun, Meltem, Genens, Mikayir, Kiremitci, Seniha, Curek, Yusuf, Gungor, N., Darendeliler, Feyza, Bundak, Ruveyde, Anik, Ahmet, Ucar, Ahmet
Přispěvatelé: OMÜ, İstinye Üniversitesi, Hastane, Akcay, Teoman, Hatun, S., Mutlu, G. Yesiltepe, Cinaz, P., Turan, S., Ekberzade, A., Bereket, A., Erbas, M. Y., Akcay, T., Onal, H., Bolu, S., Arslanoglu, I., Doger, E., Yilmaz, A. A., Ucakturk, A., Karabulut, G. S., Tuhan, H. U., Demir, K., Erdeve, S. S., Aycan, Z., Nalbantoglu, O., Kara, C., Gungor, N., Darendeliler, Feyza, Bundak, Ruveyde, Anik, Ahmet, Ucar, Ahmet, Cayir, Atilla, Ergur, Ayca Torel, Ozcabi, Bahar, Haliloglu, Belma, Ozkan, Behzat, Eklioglu, Beray Selver, Kirel, Birgul, Bezen, Digdem, Vuralli, Dogus, Unal, Edip, Sagsak, Elif, Bugrul, Fuat, Catli, Gonul, Korkmaz, Huseyin Anil, Ozbek, Mehmet Nuri, Tayfun, Meltem, Genens, Mikayir, Buyuk, Muammer, Hatipoglu, Nihal, Abali, Saygin, Kiremitci, Seniha, Curek, Yusuf, Siklar, Zeynep
Rok vydání: 2019
Předmět:
Zdroj: Diabetic Medicine. 36:1243-1250
ISSN: 1464-5491
0742-3071
DOI: 10.1111/dme.14038
Popis: siklar, zeynep/0000-0003-0921-2694; ABALI, SAYGIN/0000-0001-6552-2801; Turan, Serap/0000-0002-5172-5402; UCAKTURK, Seyit Ahmet/0000-0001-8666-4454; yesiltepe mutlu, gul/0000-0003-3919-7763; Demir, Korcan/0000-0002-8334-2422; Hatun, Sukru/0000-0003-1633-9570 WOS: 000487006600007 PubMed: 31099079 Aims To describe the baseline clinical and laboratory findings and treatment modalities of 367 children and adolescents diagnosed with Type 2 diabetes in various paediatric endocrinology centres in Turkey. Methods A standard questionnaire regarding clinical and laboratory characteristics at onset was uploaded to an online national database system. Data for 367 children (aged 6-18 years) newly diagnosed with Type 2 diabetes at 37 different paediatric endocrinology centres were analysed. Results After exclusion of the children with a BMI Z-score < 1 SD, those with genetic syndromes associated with Type 2 diabetes, and those whose C-peptide and/or insulin levels were not available, 227 cases were included in the study. Mean age was 13.8 +/- 2.2 (range 6.5-17.8) years, with female preponderance (68%). Family history of Type 2 diabetes was positive in 86% of the children. The mean BMI was 31.3 +/- 6.5 kg/m(2) (range 18.7-61) and BMI Z-score was 2.4 +/- 0.8 (range 1-5). More than half (57%) of the children were identified by an opportunistic diabetes screening due to existing risk markers without typical symptoms of diabetes. Only 13% (n = 29) were treated solely by lifestyle modification, while 40.5% (n = 92) were treated with metformin, 13% (n = 30) were treated with insulin, and 33.5% (n = 76) were treated with a combination of insulin and metformin initially. Mean HbA(1C) levels of the insulin and combination of insulin and metformin groups were 98 (11.1%) and 102 mmol/mol (11.5%), respectively, and also were significantly higher than the lifestyle modification only and metformin groups mean HbA(1C) levels (70(8.6%) and 67 mmol/mol (8.3%), respectively). Conclusions An opportunistic screening of children who are at high risk of Type 2 diabetes is essential, as our data showed that > 50% of the children were asymptomatic at diagnosis. The other important result of our study was the high rate of exclusion from the initial registration (38%), suggesting that accurate diagnosis of Type 2 diabetes in youth is still problematic, even for paediatric endocrinologists.
Databáze: OpenAIRE
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