Microparticles induce multifactorial resistance through oncogenic pathways independently of cancer cell type
| Autor: | Raquel Ciuvalschi Maia, Paloma Silva de Souza, João P. B. Viola, André L S Cruz |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Cancer Research
Carcinogenesis Antineoplastic Agents Biology P-glycoprotein medicine.disease_cause multidrug resistance Cell-Derived Microparticles microRNA medicine Humans Inhibitors of apoptosis proteins microparticles NF-kappa B General Medicine Original Articles Molecular biology Coculture Techniques Drug Resistance Multiple Multiple drug resistance MicroRNAs Oncology Apoptosis Drug Resistance Neoplasm Cancer cell biology.protein Cancer research MCF-7 Cells Signal transduction K562 Cells Proto-Oncogene Proteins c-akt K562 cells NFκB Signal Transduction |
| Zdroj: | Cancer Science |
| ISSN: | 1349-7006 1347-9032 |
| Popis: | Multidrug resistance (MDR) is considered a multifactorial event that favors cancer cells becoming resistant to several chemotherapeutic agents. Numerous mechanisms contribute to MDR, such as P-glycoprotein (Pgp/ABCB1) activity that promotes drug efflux, overexpression of inhibitors of apoptosis proteins (IAP) that contribute to evasion of apoptosis, and oncogenic pathway activation that favors cancer cell survival. MDR molecules have been identified in membrane microparticles (MP) and can be transferred to sensitive cancer cells. By co-culturing MP derived from MDR-positive cells with recipient cells, we showed that sensitive cells accumulated Pgp, IAP proteins and mRNA. In addition, MP promoted microRNA transfer and NFκB and Yb-1 activation. Therefore, our results indicate that MP can induce a multifactorial phenotype in sensitive cancer cells. |
| Databáze: | OpenAIRE |
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